Understanding the genetics behind substance use disorders
Official title: Finding the missing parts of human genetics of substance use disorders
Funded at Yale University · NIH-11168362 · Data updated 2026-11-12
This study is looking at how our genes might influence substance use disorders, with the hope of finding new ways to help people struggling with addiction by using advanced genetic testing.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | June 1, 2025 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $357,613 |
| NIH project number | 1R21DA063120-01 |
| Project ID | NIH-11168362 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a history of substance use disorders, including alcohol and cannabis use disorders.
✕Less likely to help
Patients who do not have a history of substance use disorders or those with other unrelated health conditions may not benefit from this research.
What this research studies
This research investigates the genetic factors that contribute to substance use disorders (SUDs), which are significant causes of death and disability. By utilizing whole-genome sequencing (WGS) data from biobanks, the study aims to identify both common and rare genetic variants associated with SUDs. This approach seeks to fill gaps left by previous studies that primarily focused on common variants, thereby enhancing the understanding of genetic risk factors. The ultimate goal is to improve diagnosis, prevention, and treatment strategies for individuals affected by addiction.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and personalized treatment options for individuals with substance use disorders.
How similar studies have gone: Previous research using whole-genome sequencing has shown promise in uncovering genetic factors for various conditions, suggesting potential success for this novel approach in substance use disorders.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Zhou, Hang — Yale University
- Study coordinator: Zhou, Hang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.