Condition

Alcohol Use Disorder (AUD) clinical trials and research

• 39Clinical trials
• 4NIH research projects
• 12Countries

Newest Alcohol Use Disorder (AUD) clinical trials

All recruiting trials (39)

• Imaging Mitochondrial Complex-I and Brain Metabolism in Alcohol Use Disorder

  This study tests whether PET imaging with [18F]BCPP-EF and [18F]FDG can reveal differences in brain energy use between adults with alcohol use disorder and healthy controls, and whether these measures relate to relapse risk.

  Recruiting Early Phase 1 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT07825818

• Endurance exercise to see if it lowers alcohol use in adults with AUD and ALD

  A 12-week home-based cycling program added to standard care is tested to see if it reduces alcohol use and cravings in adults with alcohol use disorder and alcohol-related liver disease.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07824089

• Do beverage cues drive craving in adults with AUD

  In adults with alcohol use disorder, this study tests whether different non-alcoholic beverage cues can trigger cravings differently when people see and smell them without drinking.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT07788716

• Semaglutide for Alcohol Use Disorder and Obesity: Testing 1.0 mg and 2.0 mg vs Placebo

  We’re testing two doses of semaglutide to see if they reduce alcohol craving and use in adults with alcohol use disorder and obesity compared with placebo.

  Recruiting at 2 sites Phase 1 Yale University · New Haven, Connecticut and 1 other locations · NCT07772960

• TRIS: a mobile app with breathalyzer to support sobriety in alcohol use disorder

  A smartphone app with a connected breathalyzer tests for abstinence and uses small financial incentives to encourage sobriety for adults with AUD in Brazil.

  Recruiting University of Sao Paulo General Hospital · São Paulo, São Paulo · NCT07735585

• Body-focused mindfulness added to inpatient alcohol use disorder treatment

  This trial tests whether a body-focused mindfulness program can help people with alcohol use disorder feel more connected to their bodies and reduce cravings while in inpatient care.

  Recruiting Medical University of Warsaw · Warsaw, Mazovian · NCT07706660

• Optimizing Smart Messaging for Alcohol Recovery

  A smartphone-based program tests whether tailored recovery messages can help people with alcohol use disorder stay engaged with support resources and improve health outcomes.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT07573540

• How urban stress patterns relate to mental illness in adults

  This study tests whether real-time environmental stress in cities is linked to depression, anxiety, or alcohol use disorders in adults 18–60 who wear a wrist sensor and use a study app.

  Recruiting at 3 sites Huashan Hospital · Beijing and 2 other locations · NCT07571226

• Tirzepatide and Brain Dopamine in Alcohol Use Disorder

  This study tests whether tirzepatide can alter brain dopamine responses and cue reactivity in people with alcohol use disorder and in healthy controls.

  Recruiting Phase 1 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07559500

• Imaging PDE4B in people with PTSD or Alcohol Use Disorder using [18F]PF974

  This study tests whether a PET tracer can image PDE4B in adults with PTSD or alcohol use disorder to better understand brain targets related to these conditions.

  Recruiting Yale University · New Haven, Connecticut · NCT07488819

• Psilocybin-assisted Therapy for people with both major depressive disorder and alcohol use disorder

  This study tests whether psilocybin-assisted therapy can be safely used and help people who have both depression and alcohol use problems.

  Recruiting Phase 2 Centre for Addiction and Mental Health · Toronto, Ontario · NCT07405606

• High-intensity brain stimulation to help with alcohol use disorder

  This pilot study tests whether high-intensity transcranial alternating current stimulation (HI-tACS) can help reduce cravings and improve self-control in adults with alcohol use disorder.

  Recruiting Shanghai Mental Health Center · Shanghai · NCT07227545

• LGBTQ+-affirming virtual therapy combining CBT and expressive writing for trauma and alcohol use

  This study will test a brief, virtual LGBTQ+-affirming therapy that combines cognitive behavioral techniques and expressive writing to see if it helps LGBTQ+ adults with PTSD and problematic alcohol use.

  Recruiting University of Rhode Island · Providence, Rhode Island · NCT07217795

• Can CBD help with alcohol withdrawal and craving

  This study tests whether cannabidiol (CBD) given with standard care can reduce withdrawal symptoms and craving in adults with moderate-to-severe alcohol use disorder during a short inpatient withdrawal period.

  Recruiting Phase 2/3 Johns Hopkins University · Baltimore, Maryland · NCT07148843

• How alcohol changes the social brain during paired interactions

  This study tests whether drinking alcohol changes brain activity and social bonding during conversations between pairs of regular social drinkers aged 21–30.

  Recruiting University of Illinois at Urbana-Champaign · Champaign, Illinois and 1 other locations · NCT07125534

• Probenecid to reduce alcohol craving and consumption

  This trial will test whether taking daily probenecid (2 g/day) reduces craving and drinking in adults with moderate-to-severe alcohol use disorder.

  Recruiting Phase 2 Brown University · Providence, Rhode Island · NCT07118618

• Smartphone app training to strengthen inhibition around alcohol or cocaine in teens and young adults

  This project will test a smartphone app that delivers alcohol- or cocaine-specific inhibition training to 14–35-year-olds in treatment for substance use disorder to see if the app is practical to use and affects drinking or drug use.

  Recruiting University of Bern · Bern · NCT07071779

• Off-label semaglutide for alcohol use disorder in people with HIV (pilot 3)

  This pilot will test whether adding off-label semaglutide plus medical management and pharmacist-delivered counseling reduces drinking in people with HIV who have alcohol use disorder and take five or more medications.

  Recruiting Phase 2 Yale University · Decatur, Georgia · NCT07040592

• Web-based mindfulness program for alcohol use recovery

  This study is testing a new online mindfulness program to help people recovering from alcohol use disorder after finishing outpatient treatment.

  Recruiting University of Georgia · Macon, Georgia and 1 other locations · NCT06987526

• Ketamine plus real-time fMRI neurofeedback for alcohol use disorder

  This trial will test whether ketamine combined with real-time fMRI neurofeedback helps adults with alcohol use disorder drink less.

  Recruiting Phase 2 Psychiatric University Hospital, Zurich · Zurich · NCT06969937

• Deep TMS targeting salience-network brain circuits to reduce relapse in Veterans with alcohol use disorder

  This trial tests whether deep transcranial magnetic stimulation (dTMS) aimed at salience-network targets can help Veterans with moderate to severe alcohol use disorder stay abstinent and lower relapse risk.

  Recruiting Stanford University · Palo Alto, California · NCT06949423

• Using baclofen to treat anxiety and alcohol use disorder

  This study is testing if baclofen can help people with alcohol use disorder who also have anxiety feel better and drink less.

  Recruiting Universitair Ziekenhuis Brussel · Jette, Brussels Capital · NCT06835907

• Assessing mental health disorders in Hong Kong using a new recall method

  This study is testing a new way to help people in Hong Kong remember important life events to see how many have experienced major depression and thoughts of suicide.

  Recruiting The University of Hong Kong · Hong Kong · NCT06804525

• Tirzepatide to reduce alcohol cravings in adults with alcohol use disorder

  This 4-week randomized, double-blind study tests whether weekly tirzepatide injections reduce cue-triggered cravings in adults with alcohol use disorder.

  Recruiting Phase 2 Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT06727331

• Understanding habits and decision-making in alcohol use disorder

  This study is trying to understand how habits and decision-making affect people with Alcohol Use Disorder compared to those without it.

  Recruiting Technische Universität Dresden · Dresden · NCT06701500

• Investigating how Pavlovian mechanisms influence substance use behaviors

  This study is testing how certain learned responses might affect substance use behaviors in people with moderate to severe substance use disorders compared to healthy individuals.

  Recruiting Technische Universität Dresden · Dresden · NCT06701487

• Suvorexant for insomnia in people with alcohol use disorder and PTSD

  This study will test whether suvorexant can reduce insomnia in adults 21–65 who have moderate-to-severe alcohol use disorder and PTSD symptoms.

  Recruiting Phase 2 Pharmacotherapies for Alcohol and Substance Use Disorders Alliance · Los Angeles, California and 1 other locations · NCT06679062

• Using Suvorexant to understand brain mechanisms in alcohol use disorder

  This study is testing whether the sleep medication Suvorexant can help people with alcohol use disorder by looking at its effects on their brain and cravings for alcohol.

  Recruiting Phase 1/2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06484075

• Sublingual dexmedetomidine (BXCL501) for people with alcohol use disorder and PTSD

  This outpatient study will try a daily sublingual dexmedetomidine film (BXCL501) for up to 28 days in adults with alcohol use disorder who also have PTSD or a qualifying trauma to see if it is safe and shows early signs of benefit.

  Recruiting Phase 1 Pharmacotherapies for Alcohol and Substance Use Disorders Alliance · West Haven, Connecticut · NCT06335407

• Using a smartphone app with medications to help Veterans manage heavy drinking

  This study is testing if using a smartphone app along with medication can help Veterans with heavy drinking manage their alcohol use better than just medication alone.

  Recruiting at 15 sites VA Office of Research and Development · Phoenix, Arizona and 14 other locations · NCT06303778

• Effects of Mavoglurant on Alcohol Craving and Drinking in Heavy Drinkers

  This study is testing if a new drug called mavoglurant can help heavy drinkers with Alcohol Use Disorder reduce their cravings and drinking.

  Recruiting at 2 sites Phase 1 Yale University · New Haven, Connecticut and 1 other locations · NCT06136195

• Psychedelic DMT for Alcohol Use Disorder

  This trial will test whether a single psychedelic dose of DMT plus a short course of psychotherapy helps people with Alcohol Use Disorder drink less.

  Recruiting Phase 1 Yale University · New Haven, Connecticut · NCT06070649

• Helping mothers with substance use issues during pregnancy

  This study is trying out a program to help mothers who have used drugs or alcohol during pregnancy get support and resources to build healthier lives for themselves and their children.

  Recruiting at 2 sites University of Oklahoma · Oklahoma City, Oklahoma and 1 other locations · NCT05534568

• LSD for people with alcohol use disorder

  This study will see if one or two doses of LSD can help adults with moderate to severe alcohol use disorder drink less and stay sober longer compared with an active placebo.

  Recruiting at 2 sites Phase 2 University Hospital, Basel, Switzerland · Basel and 1 other locations · NCT05474989

• Using N-acetylcysteine to help manage alcohol use disorder

  This study is testing if a medication called N-acetylcysteine can help people with alcohol use disorder reduce their drinking and improve their treatment results.

  Recruiting Phase 4 University of Sydney · Sydney, New South Wales and 2 other locations · NCT05408247

• Using incentives to reduce alcohol and smoking in treatment-seeking individuals

  This study is testing if a combination of rewards and a smoking cessation drug can help adults with alcohol use disorder cut down on drinking and smoking while they are getting treatment.

  Recruiting Phase 2 Washington State University · Spokane, Washington · NCT05181891

• Training to improve attention control for treating alcohol use disorder

  This study is testing a new game-like training program to see if it can help people with alcohol use disorder focus less on alcohol and improve their recovery when combined with regular treatments.

  Recruiting University of Southern Denmark · Valby, Capital Region of Denmark · NCT05102942

• Using brain stimulation to reduce alcohol cravings

  This study is testing if a type of brain stimulation can help people with alcohol use disorder reduce their cravings and drinking behavior.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT04998916

• Comparing mindfulness and relaxation techniques for treating alcohol use disorder

  This study is testing whether a mindfulness program can help people with alcohol use disorder stay sober better than a simple relaxation technique.

  Recruiting at 3 sites Centre Hospitalier Universitaire de Nīmes · Angers and 6 other locations · NCT04598399

NIH-funded research (4)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• New treatment approach to calm the stress system in alcohol use disorder

  A new, first‑in‑class medicine aims to gently calm the body’s stress system to help people with alcohol use disorder drink less and avoid relapse.

  NIH research Stress Therapeutics, INC. · San Diego, United States · NIH-11332743

• New treatment for alcohol use disorder targeting stress response

  This study is working on a new medication designed to help people with alcohol use disorder by calming down a part of the brain that can cause cravings and relapses, and it will test how well and safely this treatment works.

  NIH research Stress Therapeutics, INC. · San Diego, United States · NIH-11062330

• Using a wearable device to reduce stress and anxiety in people with alcohol use disorder

  This study is testing a new wearable device that helps reduce stress and anxiety for people dealing with alcohol use disorder by gently stimulating nerves in the skin, and it will check how well it works by looking at both physical markers and how participants feel.

  NIH research Soovu Labs INC · Seattle, United States · NIH-10917870

• Investigating the effects of DMT on alcohol use disorder

  This study is looking at whether a single dose of a psychedelic called DMT, combined with some therapy, can help people who are having trouble with alcohol use, and it will check how safe and well-tolerated DMT is during the process.

  NIH research Yale University · New Haven, United States · NIH-10904027

Related topics

Quick answers

How many Alcohol Use Disorder (AUD) clinical trials are recruiting right now?

39, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in United States (24 trials), Switzerland (3 trials), Germany (2 trials), China (2 trials), Australia (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 8, Phase 1: 5, Phase 1/2: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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