Condition

Substance Use clinical trials and research

As of November 12, 2026, Find a Trial lists 46 Substance Use clinical trials that are recruiting, at sites in 6 countries (most in United States (40), Thailand (4), Canada (1)). By phase: Phase 2 (2), Phase 4 (1), Phase 1 (1). The most active sponsors are Johns Hopkins Bloomberg School of Public Health (5), Institute of HIV Research and Innovation Foundation, Thailand (4), Brown University (3). There are also 519 NIH-funded research projects on Substance Use, with $282.1 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.

Newest Substance Use clinical trials

StudyPhaseWhereStatusRegistered
iPAWS: Helping teens manage pain and risky behaviors after wisdom tooth removal — Providence, Rhode Island Recruiting Jul 28, 2026
Returning to the Land intervention for families in a tribal community — Box Elder, Montana Recruiting Jul 10, 2026
Connecting incarcerated adults with virtual peer recovery coaches to support addiction care — Atlanta, Georgia and 2 other locations Recruiting May 4, 2026
Screening and brief counseling for substance use in adult survivors of childhood cancer — Memphis, Tennessee Recruiting Apr 7, 2026
Host-led harm reduction for men who have sex with men who engage in chemsex in Bangkok — Pathum Wan, Bangkok Recruiting Apr 6, 2026
Transgender-tailored harm reduction and PrEP service for people who engage in chemsex in Bangkok — Pathum Wan, Bangkok Recruiting Apr 6, 2026
Adding sexual-pleasure conversations to harm reduction services for MSM and transgender people who do chemsex in Thailand — Pathum Wan, Bangkok Recruiting Apr 3, 2026
Developing transgender-tailored chemsex harm-reduction services in Thailand — Pathum Wan, Bangkok Recruiting Apr 1, 2026
Project REACH: Telehealth at syringe service programs to help people who use drugs access HIV-related care — Minneapolis, Minnesota Recruiting Feb 25, 2026
Emotional Empowerment and Lifelong Strength for young Black adults — Piscataway, New Jersey Recruiting Jan 30, 2026

All recruiting trials (46)

NIH-funded research (newest 40 of 519)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

Related topics

HIV PreventionSexually Transmitted Infections (STIs)AnxietyHIVHIV InfectionsMental HealthSubstance Use DisordersAdolescent BehaviorAlcohol Use, UnspecifiedCannabis UseChemsexMental Health IssueSubstance AbuseAddiction

Quick answers

How many Substance Use clinical trials are recruiting right now?

46, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (40 trials), Thailand (4 trials), Canada (1 trial), South Africa (1 trial), Zambia (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 4: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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Last reviewed 2026-11-12 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.