Condition

Substance Abuse clinical trials and research

• 15Clinical trials
• 24NIH research projects
• 7Countries

Newest Substance Abuse clinical trials

All recruiting trials (15)

• Hybrid DBT for Veterans to Further Reduce PTSD and Emotion Regulation Problems

  This study tests a hybrid dialectical behavior therapy program for veterans with PTSD and emotion regulation issues to see if it helps reduce symptoms and improve daily functioning.

  Recruiting Arkin · Amstelveen, North Holland · NCT07652645

• Brain imaging to predict teens' response to cannabis treatment

  This project will test whether teens' brain activity during a learning task can predict how well 14–17-year-olds do in a 10-week virtual reward program to reduce cannabis use.

  Recruiting Indiana University · Indianapolis, Indiana · NCT07340554

• A program for transgender adults to support recovery from substance use and HIV risk

  This study is testing a support program for transgender adults to see if it can help them reduce substance use and lower their risk of HIV.

  Recruiting Illinois Institute of Technology · Chicago, Illinois · NCT06880705

• Improving substance misuse prevention policy using research evidence

  This study is testing a new way to help state lawmakers use research to create better laws for preventing substance misuse.

  Recruiting Penn State University · University Park, Pennsylvania · NCT06856148

• Improving substance use services in Oregon through data-driven decision-making

  This study is testing a new way to help Oregon's service providers and health officials use data better to improve substance use services and reduce overdoses.

  Recruiting Chestnut Health Systems · Eugene, Oregon · NCT06852170

• Long-term high-dose lisdexamfetamine treatment for methamphetamine use disorder

  This trial will try giving adults with moderate to severe methamphetamine use disorder a 25-week course of high-dose lisdexamfetamine plus their usual care to see if it helps them stay in treatment and cut down on methamphetamine use compared with placebo.

  Recruiting Phase 2 Centre hospitalier de l'Université de Montréal (CHUM) · Montreal, Quebec · NCT06788587

• SER Familia: A family program to reduce acculturative stress and build resilience in Latino immigrant families.

  This program tests whether a six-session, community health worker–delivered family intervention can lower acculturative stress and reduce risks for substance use, intimate partner violence, HIV, depression, and anxiety among first-generation Latino immigrant parents and their 12–17-year-old children.

  Recruiting Duke University · Durham, North Carolina · NCT06627764

• Early intervention for alcohol and substance abuse in adolescents

  This study is testing if an online program can help teenagers aged 14-20 at a psychiatric clinic reduce their alcohol and substance use by checking in with them before and after six months.

  Recruiting Kuopio University Hospital · Kuopio · NCT06262958

• School-based program to prevent substance abuse among adolescents

  This study is testing a new school program aimed at helping kids aged 13-15 in Pokhara, Nepal, learn how to avoid substance abuse through activities like storytelling and role-play.

  Recruiting Manipal College of Nursing · Pokhara, Gandaki and 2 other locations · NCT06004726

• Mobile app for teens and parents to reduce substance use

  A teen-focused mobile app plus parent support is being tested to see if it helps teens reduce substance use and improve related mental health, with or without extra parent support, compared to receiving online resources.

  Recruiting at 2 sites Evidence-Based Practice Institute, Seattle, WA · Baltimore, Maryland and 1 other locations · NCT05897164

• Assessing harm reduction services for drug users

  This study is testing a new approach to help Black and Latinx individuals who use drugs get better support and services compared to the usual options.

  Recruiting at 2 sites NYU Langone Health · New Haven, Connecticut and 2 other locations · NCT05776316

• Comparing Lemborexant, Zopiclone, and Clonidine for treating insomnia in chronic pain patients

  This study is testing whether Lemborexant, Zopiclone, or Clonidine can help people with chronic pain sleep better and manage their pain.

  Recruiting Salem Anaesthesia Pain Clinic · Surrey, British Columbia · NCT05618002

• Free dental treatment for patients in substance abuse rehabilitation

  This study tests whether offering free dental care to people in substance abuse rehab helps them use the services and supports their recovery process.

  Recruiting University Hospital of North Norway · Narvik, Nordland · NCT05606562

• Examining brain connectivity in suicidal opioid users

  This study is trying to see if a brain stimulation treatment can help reduce cravings and suicidal thoughts in people who use opioids.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT05489042

• Treatment for voiding dysfunction caused by substance abuse

  This study is trying to find the best way to help people with bladder problems caused by drug use, especially in Hong Kong, by testing different treatments and support options.

  Recruiting Chinese University of Hong Kong · Shatin · NCT03913819

NIH-funded research (24)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• An integrated mobile health program to reduce SAVA and mental health problems among female sex workers in Kenya

  A new mobile health program aims to help female sex workers in Kenya avoid substance abuse, violence, HIV, and depression by delivering group therapy, online resources, and a peer discussion space.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11625516

• Neurobiological signs of resilience and recovery from substance abuse in youth who faced childhood adversity

  A long-term study will explore brain patterns in young people who faced childhood adversity to understand why some stay resilient and avoid substance problems.

  NIH research Mclean Hospital · Belmont, United States · NIH-11458394

• Illuminating how brain peptides control withdrawal in methamphetamine use

  A new NIH grant aims to build precise chemical tools to turn brain peptide signals on or off, helping people who are withdrawing from methamphetamine.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11388531

• Molecular Pathways of Innate Immunity and Substance Abuse in NeuroHIV

  A new project will explore how HIV and methamphetamine together cause brain inflammation, with the goal of understanding why some people living with HIV experience neurocognitive problems.

  NIH research Rush University Medical Center · Chicago, United States · NIH-11384793

• How neighborhood stigma and support relate to substance use and HIV risk for Black and Latino bisexual men

  This project looks at how local stigma and supportive places in daily life relate to substance use and HIV risk among Black and Latino bisexual men.

  NIH research Florida State University · Tallahassee, United States · NIH-11377090

• How methamphetamine and immune signals affect the brain in people with HIV

  This project tests whether methamphetamine together with HIV turns on a specific immune alarm pathway (cGAS/STING) in brain cells of people living with HIV who use methamphetamine.

  NIH research Rush University Medical Center · Chicago, United States · NIH-11364824

• Innovative imaging to map HIV reservoirs in the brain and CNS with substance use

  A new imaging approach will create 3D maps of HIV reservoirs in the brain and nearby CNS tissues in the context of substance abuse, to better understand where and how the virus hides.

  NIH research University of Florida · Gainesville, United States · NIH-11345614

• Virginia Patient Engagement Resource Center to Improve Substance Use Treatment

  Aimed at improving substance use treatment by listening to adults in Virginia communities most affected and building a patient advisory panel to guide research.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11323543

• Integrative mobile program to prevent SAVA and mental health problems among female sex workers in Kenya

  A new smartphone-based program helps female sex workers in Kenya manage substance use, violence exposure, HIV risk, and mental health through group sessions, supportive online resources, and a community forum.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11307355

• New imaging techniques to visualize HIV reservoirs in the brain related to substance abuse

  This study is looking at how HIV hides in the brain, especially for people who use drugs, by using special imaging techniques to see where the virus is located and how much there is, so we can better understand its effects.

  NIH research University of Florida · Gainesville, United States · NIH-11160708

• Improving substance abuse treatment for underserved communities in Virginia

  This study is working to improve treatment for people with substance use disorders in Virginia by creating a center where those in recovery can share their experiences and help shape better support and services, especially for those in underserved communities.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11124753

• Innovative education program to improve substance abuse prevention and treatment

  This study is all about helping scientists who work on Substance Use Disorders learn how to turn their research ideas into real-world solutions, with a special program at Johns Hopkins University that offers online courses and support to make that happen.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11093401

• Understanding how HIV and Methamphetamine affect brain inflammation

  This study is looking at how HIV and meth use affect brain inflammation and thinking skills in people living with HIV/AIDS, with the goal of finding ways to help improve brain health for those affected.

  NIH research Rush University Medical Center · Chicago, United States · NIH-10933000

• Exploring how neighborhoods affect substance use and mental health in urban youth

  This study looks at how the neighborhoods where young people live in Paterson, New Jersey, affect their mental health and substance use, with the goal of finding new ways to help them based on their community's needs.

  NIH research Yale University · New Haven, United States · NIH-10914665

• Investigating substance abuse disorders during pregnancy and childhood

  This study is all about helping pregnant people, new moms, and their kids who are dealing with substance use issues by training a diverse group of healthcare professionals to provide better support and care for these families.

  NIH research Magee-Women's Res Inst and Foundation · Pittsburgh, UNITED STATES · NIH-10912784

• How sleep and biological rhythms affect substance abuse risk in teens

  This study is looking at how sleep habits and body clocks affect the chances of teens developing problems with drugs or alcohol, and it aims to find ways to help keep young people safe from substance abuse.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10892098

• Training future researchers in substance use disorders at CDU and UCLA

  This program is designed to help students from underrepresented backgrounds learn about substance use disorders through hands-on research, skill-building classes, and guidance from experienced mentors at Charles R. Drew University and UCLA.

  NIH research Charles R. Drew University of Med & Sci · Los Angeles, United States · NIH-10862765

• Investigating how HIV and opioids affect stroke risk and recovery

  This study is looking at how HIV brain infection and using prescription opioids might increase the risk of strokes in people living with HIV, and it aims to find ways to protect the brain and improve recovery for those affected.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-10860986

• Improving HIV care by integrating substance use treatment

  This study is looking at how adding motivational interviewing for substance use treatment can improve care for people living with HIV, making it easier for them to get the support they need in their communities.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-10851036

• Training Indigenous scientists to address substance abuse and addictions

  This program is all about helping Indigenous students become researchers who will study and find solutions for substance abuse and addiction issues in American Indian and Alaska Native communities, so they can better understand and support their own people.

  NIH research University of Washington · Seattle, United States · NIH-10838557

• A mobile health intervention for youth with substance abuse and related issues

  This study is testing a new mobile app called ePACE that helps young people in the juvenile justice system who are dealing with substance use and other challenges, giving them personalized support and choices to improve their health and well-being.

  NIH research Oregon Research Institute · Springfield, UNITED STATES · NIH-10832027

• Developing new methods to monitor brain proteins related to substance use disorders

  This study is looking at how drug use affects proteins in the brain to better understand addiction, using new methods to collect and analyze these proteins, which could help improve treatment for people struggling with substance use disorders.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10798157

• Training future American Indian and Alaska Native scientists in substance abuse research

  This program is designed to help young American Indian and Alaska Native people become scientists who can tackle substance abuse issues in their communities by offering them education, mentorship, and hands-on experiences that respect their culture.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-10690509

• Training future experts in understanding and treating substance abuse

  This program at the University of Miami is designed to help students learn how to study substance abuse, so they can better understand how drugs affect people and improve treatment options.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-10611853

Related topics

Quick answers

How many Substance Abuse clinical trials are recruiting right now?

15, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in United States (8 trials), Canada (2 trials), Norway (1 trial), Nepal (1 trial), Finland (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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