Using brain stimulation to reduce cravings in methamphetamine users

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project investigates the effects of high frequency repetitive transmagnetic stimulation (HF-rTMS) on cue-induced cravings in adults with methamphetamine use disorder. Participants who have recently abstained from methamphetamine will be randomly assigned to receive either real or sham rTMS while being exposed to methamphetamine-related or neutral visual cues. The study aims to determine if stimulation of the left dorsolateral prefrontal cortex can effectively reduce cravings for methamphetamine. The outcomes will be measured using validated craving assessments.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Subjects must use at least 0.5 g per day at least 5 days per week and have a minimum 12-month history of METH abuse.
* Subjects must meet DSM V diagnosis for methamphetamine use disorder.
* Subjects must have a minimum 4-week period of detoxification and a desire to stop using methamphetamine.

Exclusion Criteria:

* Present or past history of neurological disorder
* The present history of a DSM IV Axis I or DSM V primary psychiatric disease (apart from MUD and depressive symptoms defined as a Hamilton Depression Scale Score \< 7 ("normal"))
* Scores on the Hamilton Depression Scale \> 8, possibly indicating clinical depression
* No current abuse of drugs other than methamphetamine (except nicotine). Urine-screening tests for psychoactive drugs will be performed to corroborate the lack of drug use.
* Individuals meeting criteria for cannabis use disorder or alcohol use disorder
* Medical illness that can affect brain function
* Past or present history of cardiovascular disease or high blood pressure
* Any history of epilepsy or a known history of seizure disorder
* A history of metal in the head or chest area (except dental fillings or braces)
* Current consumption of psychiatric medication
* Any other medical, neurological or neurosurgical condition that would preclude the administration of repetitive transmagnetic stimulation

Where it's running

• Veterans Affairs Portland Health Care System
  Portland, Oregon, United States Recruiting

Study contacts

• Study coordinator: Brandon J Cornejo, MD, PhD
• Email: brandon.cornejo@va.gov
• Phone: 503-721-7964

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.