Clinical trial Recruiting at 3 sites Interventional Ages 18 and up

Support for families grieving an overdose loss

Official title: Families Left Behind: Addressing Prolonged Grief and Substance Use Disorders Among People Bereaved by Drug Overdose Deaths

Run by Rand · NCT06854757 · Data updated 2026-11-12

This project will test a peer-led grief support program called RIVER to help adults who lost a loved one to an unintentional drug overdose within the past year.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment340 (estimated)
SponsorRand
Academic / other
Locations4 sites (Birmingham, Alabama and 3 other locations)
StatusRecruiting
StartedJune 13, 2025
Main results expectedAugust 29, 2026
Study endsOctober 2030
Registry record updatedAugust 21, 2025
Trial IDNCT06854757 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults 18 and older who fluently read English or Spanish, can give consent, and who lost a loved one to an unintentional drug overdose within the past year are the intended participants.

Probably not a fit

People with active suicidal ideation, those requiring psychiatric or substance-use hospitalization, anyone whose loss was more than one year ago, or whose loved one died by suicide or undetermined intent may not be appropriate or benefit from this program.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study compares a peer-delivered grief support program (RIVER) with enhanced care as usual for people bereaved by unintentional drug overdose. Participants are identified through collaborating medical examiner offices and work with Peer Support Community Partners alongside research teams from RAND and Stanford. Eligible adults (18+) who lost a loved one to an unintentional overdose within the past year and who can consent will be enrolled; people with active suicidal ideation or recent psychiatric hospitalization are excluded. Outcomes will include measures of prolonged grief, substance use, PTSD, depression, and related risk behaviors.

Why it matters

Potential benefit: If successful, the program could reduce prolonged grief symptoms and lower the risk of substance misuse and suicidal thoughts among people bereaved by overdose.

How similar studies have gone: Peer grief support interventions have shown promise in bereavement and behavioral health settings, but rigorous trials specifically targeting overdose bereavement remain limited.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* people who lost a loved one to an unintentional drug overdose death within the past year
* age 18 and older
* fluently understand English or Spanish
* have the capacity to give consent (e.g., excluding those with severe cognitive impairment, those in active psychosis, and those with developmental disabilities).

Exclusion Criteria:

* people who need hospitalization for psychiatric symptoms or substance use disorders. (Note, people who use drugs but who do not require hospitalization will be included.)
* people have active suicidal ideation
* people who lost someone to a drug overdose death more than one year ago
* people who lost someone to a drug overdose death that was suicidal in nature or of undetermined intent

Where it's running

  • Jefferson County Coroner/Medical Examiner's Office
    Birmingham, Alabama, United States
    Recruiting
  • San Diego County Medical Examiner Office
    San Diego, California, United States
    Recruiting
  • Connecticut Office of the Chief Medical Examiner
    Farmington, Connecticut, United States
    Recruiting
  • Peer Support Community Partners
    Watertown, Massachusetts, United States
    Active not recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.