Adaptive design optimization to create rapid, reliable behavioral tests for substance use disorders
Official title: Utility of adaptive design optimization for developing rapid and reliable behavioral paradigms for substance use disorders
Funded at Virginia Commonwealth University · NIH-11399689 · Data updated 2026-11-12
Aims to speed up and improve the reliability of behavioral tests used to understand and treat substance use disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project start | September 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $342,261 |
| NIH project number | 5R01DA058038-04 |
| Project ID | NIH-11399689 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with substance use disorders who can complete computerized and behavioral tasks in a research setting.
✕Less likely to help
Patients who cannot engage with computerized assessments or who have urgent clinical needs outside research participation.
What this research studies
This project will adapt Bayesian design methods to optimize existing tasks that measure executive function, incentive motivation, and negative mood in people with substance use disorders. The goal is to shorten assessments, increase precision, and better capture underlying causes. The approach blends fast, data-driven updates with multi-domain batteries to yield robust, patient-friendly measures. If successful, these improved tests could guide personalized treatment decisions and biomarker development.
Why it matters
Potential benefit: Could lead to quicker, more accurate assessments that help tailor treatments for individuals with substance use disorders.
How similar studies have gone: Prior work using adaptive designs has improved measurement efficiency in cognitive tasks, with promising results for neurobehavioral assessment.
Where this research is happening
-
Virginia Commonwealth University
Richmond, United States Active
Researchers
- Principal investigator: Vassileva, Jasmin L — Virginia Commonwealth University
- Study coordinator: Vassileva, Jasmin L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.