Clinical decision support to spot relapse risk early in teens with substance use disorders
Official title: Clinical Decision Support for Early Detection of Relapse Risk in Adolescents with Substance Use Disorders
Funded at Pillsmart INC. · NIH-11316815 · Data updated 2026-11-12
A new tool called LEVL helps clinicians spot early signs that a teen recovering from substance use might relapse, so they can intervene sooner.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pillsmart INC. NIH-funded |
| Lab location | 1 site (Brooklyn, United States) |
| Project start | June 1, 2026 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $399,993 |
| NIH project number | 1R43DA065414-01 |
| Project ID | NIH-11316815 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adolescents and young adults with current or prior substance use disorders who are in or exiting treatment.
✕Less likely to help
Patients without access to digital health tools or those not using or engaging with mobile health support may see limited benefit.
What this research studies
This project develops a teen-focused clinical decision support system that uses physiological data, behavior, and environment to flag relapse risk. It includes a mobile app for adolescents to support self-management and timely actions by clinicians. The study will test usability, clinician adoption, and a preliminary predictive model in a 90-day feasibility trial, with plans to evaluate actual relapse prevention in future phases.
Why it matters
Potential benefit: If successful, LEVL could help reduce relapse rates among adolescents by enabling earlier, targeted interventions.
How similar studies have gone: Previous work shows digital CDS tools can aid relapse prevention in behavioral health, but adolescent-specific feasibility is still needed.
Where this research is happening
-
Pillsmart INC.
Brooklyn, United States Active
Researchers
- Principal investigator: Perse, Artin — Pillsmart INC.
- Study coordinator: Perse, Artin
Related research
Other NIH-funded projects on the same topics.
-
Improving contraception decisions for women with substance use disorders after childbirth
A patient-centered decision tool called MyPath aims to help postpartum women with substance use disorders choose and keep effective contraception after giving birth.
-
Transforming prison care for HIV, HIV risk, and substance use disorders
A patient-friendly look at improving HIV care and prevention for people in state prisons, especially where substance use is common.
-
Genetic factors behind alcohol and opioid use disorders and depression in veterans
A study using genetic data from veterans to understand how genes contribute to co-occurring alcohol use, prescription opioid use, and depression.
-
Written Exposure Therapy for Veterans with PTSD and Substance Use Disorder (brief trauma treatment)
A brief trauma-focused therapy called Written Exposure Therapy is being studied to help veterans who have both PTSD and substance use disorders.
-
Web-based training to treat PTSD and substance use together in Veterans
A web-based training resource helps VA clinicians learn how to provide integrated treatment for Veterans with both PTSD and substance use disorders.
-
Mobile health support to help Veterans with substance use disorders function better after treatment
A smartphone app, based on Motivational Enhancement Therapy, is being developed to help Veterans stay on track and function better after leaving residential substance use treatment.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.