Condition

Sleep Apnea clinical trials and research

• 34Clinical trials
• 169NIH research projects
• 1New in 30 days
• 15Countries

Newest Sleep Apnea clinical trials

All recruiting trials (34)

• Oura Ring validation for sleep using gold-standard sleep tests

  This study tests how well the Oura Ring matches the gold-standard sleep test ( PSG ) in healthy adults and people with sleep apnea.

  Recruiting Ouraring Inc. · St Louis, Missouri · NCT07908199

• Left-atrial Fibrosis in Persistent Atrial Fibrillation and Its Comorbidities

  This study tests how comorbid conditions like sleep apnea and primary aldosteronism relate to left-atrial fibrosis and AF recurrence in patients undergoing ablation.

  Recruiting University Hospital Augsburg · Augsburg, Bavaria · NCT07857044

• Using a sleep medication to help people with obstructive sleep apnea tolerate CPAP

  The trial will test whether giving the sleep medicine eszopiclone to people with obstructive sleep apnea (AHI ≥10/hour) helps them stick with CPAP and improves thinking skills.

  Recruiting Phase 3 Yale University · North Haven, Connecticut · NCT07332442

• Neurostimulation treatment for sleep-disordered breathing

  This trial will test whether the Lunair Alpha System, a small implanted neurostimulator, can reduce breathing problems during sleep for people with moderate to severe sleep apnea who cannot tolerate or access other treatments.

  Recruiting Lunair Medical · Panama City, Provincia de Panamá · NCT07243405

• IBI362 for Chinese adults with obstructive sleep apnea and BMI ≥28

  This trial will see if once-weekly IBI362 injections help Chinese adults with moderate-to-severe obstructive sleep apnea who have a BMI of 28 or higher.

  Recruiting Phase 3 Innovent Biologics (Suzhou) Co. Ltd. · Beijing · NCT06931028

• Neurostimulation treatment for sleep apnea

  This study tests a new implant that uses neurostimulation to see if it can help people with moderate to severe sleep apnea who can't use regular treatments.

  Recruiting Lunair Medical · Asunción, Paraguay · NCT06883617

• Understanding Obstructive Sleep Apnea in Italy

  This study is trying to gather information about how common Obstructive Sleep Apnea is in Italy and what it looks like in patients to better understand the condition.

  Recruiting at 18 sites Istituto Auxologico Italiano · Acri and 29 other locations · NCT06872242

• Comparing cardiac variability in sleep apnea and healthy individuals

  This study is testing how heart rate changes during sleep in people with severe sleep apnea compared to healthy individuals to see if it can help create a better way to screen for sleep apnea.

  Recruiting University Hospital, Lille · Lille · NCT06808464

• Understanding the relationship between sleep disordered breathing and multiple health conditions

  This study is trying to see how sleep problems affect people's overall health and quality of life by looking at different health conditions in patients with sleep disordered breathing.

  Recruiting Xiangya Hospital of Central South University · Changsha · NCT06755840

• Home testing for sleep apnea to improve well-being in patients with atrial fibrillation

  This study is testing if home testing and treatment for sleep apnea can help people with atrial fibrillation feel better and improve their quality of life.

  Recruiting Herlev and Gentofte Hospital · Hellerup · NCT06618417

• Daytime versus overnight titration for hypoglossal nerve stimulation

  We will test whether a daytime sleep test works as well as an overnight sleep test to fine-tune hypoglossal nerve stimulation for people with moderate to severe obstructive sleep apnea.

  Recruiting University Hospital, Antwerp · Edegem, Antwerp · NCT06559956

• Janus II: dual-channel implant for severe sleep apnea

  This study will test a dual-channel implant (remedē® Dual Channel System) in adults with severe sleep apnea to see if it can be implanted safely and improve breathing during sleep.

  Recruiting at 4 sites Zoll Medical Corporation · Scottsdale, Arizona and 3 other locations · NCT06556693

• Registry of patients with sleep apnea and daytime sleepiness

  This study is trying to learn more about people with sleep apnea and daytime sleepiness by tracking their health and treatment over two years.

  Recruiting Hospital San Pedro de Logroño · Logroño, La Rioja · NCT06514482

• Examining the impact of laryngomalacia on children's quality of life before and after treatment

  This study looks at how laryngomalacia affects the quality of life for children and sees if treatment, including surgery, can help them feel better.

  Recruiting at 2 sites Oslo University Hospital · Oslo and 1 other locations · NCT06464757

• Effects of CPAP on cholesterol and uric acid levels in patients with sleep apnea and high cholesterol

  This study tests if using a CPAP machine for a year can help people with sleep apnea and high cholesterol lower their cholesterol and uric acid levels while also improving their overall health.

  Recruiting Phase 4 Hospital Universitario La Paz · Coslada, Madrid · NCT06463561

• Registry for patients with obstructive sleep apnea treated with hypoglossal nerve stimulation

  This study is collecting information from patients with moderate to severe obstructive sleep apnea who are using a new device called Inspire to see how well it works and how it helps them over five years.

  Recruiting at 2 sites University Hospital, Antwerp · Edegem, Antwerp and 1 other locations · NCT06332404

• Personalized treatment for sleep apnea and its effects on Alzheimer's in Black patients

  This study tests a personalized treatment plan for sleep apnea to see if it helps older Black patients with the condition also improve their Alzheimer's symptoms and brain health.

  Recruiting University of Miami · Miami, Florida · NCT06089161

• Understanding health improvements after mini gastric bypass surgery

  This study looks at how mini gastric bypass surgery can improve health issues related to obesity, like diabetes and sleep apnea, by tracking changes in body weight and other health markers after the surgery.

  Recruiting All India Institute of Medical Sciences, Bhubaneswar · Bhubaneswar, Odisha · NCT06015620

• Effects of CPAP on COPD and Sleep Apnea Overlap Syndrome

  This study is testing if using a CPAP machine can help people with both COPD and sleep apnea feel better and reduce health problems over a year.

  Recruiting at 15 sites University Hospital, Angers · Angers and 14 other locations · NCT05958563

• Using bexagliflozin to treat sleep apnea in overweight or obese adults

  This study is testing if a medication called bexagliflozin can help overweight or obese adults with sleep apnea breathe better while they sleep.

  Recruiting at 2 sites Phase 4 Yale University · New Haven, Connecticut and 1 other locations · NCT05612594

• Investigating the link between obstructive sleep apnea and pulmonary hypertension

  This study looks at how common sleep apnea is in adults with pulmonary hypertension and how it affects their health.

  Recruiting Chinese Pulmonary Vascular Disease Research Group · Beijing · NCT05595200

• Investigating treatments for sleep apnea in veterans using opioids

  This study is testing whether certain treatments can help veterans with sleep apnea who use opioids breathe better and improve their quality of life.

  Recruiting Phase 1/2 VA Office of Research and Development · Detroit, Michigan · NCT05589753

• Hypercapnia treatment for respiratory recovery in spinal cord injury patients

  This study tests if daily hypercapnia treatments can help veterans with spinal cord injuries breathe better and reduce sleep apnea symptoms.

  Recruiting VA Office of Research and Development · Detroit, Michigan · NCT05536076

• Registry of patients with sleep disorders

  This study is collecting information from people with sleep disorders to see how these conditions affect their lives and to track their progress over time.

  Recruiting Johannes Gutenberg University Mainz · Mainz, Rhineland-Palatinate · NCT05321355

• Exploring the relationship between sleep health and overall well-being

  This study is trying to see how sleep affects both physical and mental health by tracking the sleep and activity of people using digital devices.

  Recruiting Scripps Translational Science Institute · La Jolla, California · NCT05197738

• Sleep apnea and how it affects shunts in normal-pressure hydrocephalus

  This project will measure intracranial and intra-abdominal pressures during sleep in people with normal-pressure hydrocephalus to see if sleep apnea affects shunt function and whether treating sleep apnea improves symptoms.

  Recruiting University of Valencia · Valencia, Valencia · NCT04471740

• Evaluating a new sleep apnea detection device for children

  This study is testing a new device to see if it can effectively detect sleep apnea in children compared to the standard sleep test.

  Recruiting at 2 sites Acurable Ltd. · Sheffield and 1 other locations · NCT04031950

• Improving sleep-related issues in spinal cord injury patients with CPAP therapy

  This study is testing if using CPAP therapy at night can help improve sleep problems and overall well-being in adults with spinal cord injuries who have breathing issues during sleep.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT04007380

• Using oxytocin nasal spray to reduce CPAP pressure in sleep apnea patients

  This study is testing if a nasal spray with oxytocin can help people with sleep apnea use lower pressure on their CPAP machines while they sleep.

  Recruiting Phase 1 George Washington University · Washington D.C., District of Columbia · NCT03860233

• How changes in brain blood flow affect breathing during sleep

  This project will test whether temporarily lowering blood flow to the brain changes how healthy adults' breathing responds to low oxygen and high carbon dioxide during normal sleep and short periods of low oxygen.

  Recruiting Phase 1/2 University of Calgary · Calgary, Alberta · NCT03255408

• Treatment for sleep apnea in patients with cervical spinal cord injuries

  This study tests new ways to help people with cervical spinal cord injuries who have sleep apnea by looking at how low oxygen levels and extra oxygen can affect their breathing during sleep.

  Recruiting Phase 4 John D. Dingell VA Medical Center · Detroit, Michigan · NCT02922894

• Investigating treatments for sleep apnea in elderly veterans

  This study is testing whether oxygen, finasteride, and acetazolamide can help elderly veterans with sleep apnea breathe better while they sleep.

  Recruiting Phase 4 VA Office of Research and Development · Detroit, Michigan · NCT02703220

• Combining oxymetazoline and fluticasone to improve sleep apnea symptoms

  This study is testing if using a nasal spray that combines two medications can help people with mild sleep apnea and nasal congestion breathe better at night.

  Recruiting Phase 4 University of South Florida · Tampa, Florida · NCT02630121

• Program to reduce blood pressure in sleep apnea patients with resistant hypertension

  This study is testing if a physical activity program combined with CPAP treatment can help people with sleep apnea and high blood pressure better control their blood pressure throughout the day.

  Recruiting at 3 sites AGIR à Dom · Québec and 4 other locations · NCT02057783

NIH-funded research (newest 40 of 169)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Improving WTC responder mental health with personalized sleep treatment for COMISA

  Aimed at helping World Trade Center responders who have both insomnia and sleep apnea feel better by using a tailored combination of sleep therapies.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11578881

• Central sleep apnea: how combined therapies could help you breathe better

  This NIH grant explores how a combination of therapies, including a breathing device and a drug, might reduce central sleep apnea for people with heart failure or opioid use, by targeting the body’s breathing control system.

  NIH research John D Dingell VA Medical Center · Detroit, United States · NIH-11516980

• Mechanisms of sex-specific responses to sleep apnea therapies

  A research project at NYU School of Medicine is exploring how men and women may respond differently to treatments for obstructive sleep apnea and related heart risk.

  NIH research New York University School of Medicine · New York, United States · NIH-11446170

• Deep learning to predict obstruction site and guide sleep apnea treatment

  A patient-focused project uses snoring sounds and AI to predict where your airway collapses during sleep and to guide personalized treatments.

  NIH research Kennesaw State University · Kennesaw, United States · NIH-11445428

• Personalized DISE-guided surgery for sleep apnea in children with Down syndrome

  A personalized surgical approach guided by DISE sleep-endoscopy is being tested to better treat sleep apnea in children with Down syndrome who don’t always improve after standard surgery.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11422377

• Biomarkers to understand obstructive sleep apnea using microRNAs

  A study at the University of Pennsylvania will look for microRNA signs in the blood that reflect how bad sleep apnea is and how well CPAP therapy works for patients.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11419858

• Personalized sleep apnea care using genetics and biomarkers

  A patient-friendly look at a research program aiming to tailor sleep apnea care using genetics, biomarkers, and brain/body signals to improve prediction and prevention.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11419810

• Night-to-night sleep-disordered breathing differences in women and men

  A study to find better biomarkers for sleep apnea severity, especially in women, by monitoring people at home for a week and tracking daily mood and energy.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11419262

• Contactless, engagement-free sleep apnea monitoring for home care

  A device-enabled system uses noncontact sensors and AI to monitor sleep apnea at home, helping adults manage risk from sleep-related breathing problems.

  NIH research University of Georgia · Athens, United States · NIH-11417856

• Personalized surgery options for kids with sleep apnea and small tonsils

  This compares a personalized, sleep-endoscopy–guided surgical plan with the standard tonsil-and-adenoid removal for children with obstructive sleep apnea and small tonsils.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11417824

• Understanding how brain circuits control breathing during sleep problems and related conditions

  Researchers are studying specific brain circuits that control breathing and wakefulness in conditions like sleep apnea, opioid-related breathing problems, and obesity-related breathing issues, with the goal of finding new ways to treat these problems.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11415571

• Positive airway pressure therapy for older veterans with COPD and sleep apnea overlap

  A plan to see if using a CPAP/BAP therapy improves sleep, thinking, and quality of life for older veterans who have both COPD and sleep apnea.

  NIH research John D Dingell VA Medical Center · Detroit, United States · NIH-11415408

• ENT-guided cervical nerve stimulation for central sleep apnea

  A new, less invasive outpatient procedure to stimulate the phrenic nerve could help people with central sleep apnea breathe better at night.

  NIH research Coridea, LLC · New York, United States · NIH-11414970

• Obstructive sleep apnea and blood sugar control in adults with type 1 diabetes

  This study tests whether treating sleep apnea improves blood sugar control in adults with type 1 diabetes who use insulin pumps and continuous glucose monitoring.

  NIH research University of Chicago · Chicago, United States · NIH-11412692

• Oxygen therapy for kids with Down syndrome and sleep apnea

  A study tests whether low-flow oxygen helps children with Down syndrome and moderate to severe obstructive sleep apnea who have not benefited from first-line surgery.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11411366

• Understanding sleep apnea better with new imaging during sleep

  Aiming to map exactly where and how the airway collapses during sleep using innovative imaging, to help tailor better treatments for people with sleep apnea.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11408565

• SGLT2 inhibitors and sleep apnea outcomes in overweight adults

  This study tests whether an SGLT2 inhibitor can improve sleep apnea-related health issues in overweight adults with moderate to severe sleep apnea.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11402545

• 3D MRI to understand airway collapse in sleep apnea

  A new 3D dynamic MRI method will help doctors see how the airway collapses during sleep in people with obstructive sleep apnea, especially those who don’t tolerate CPAP.

  NIH research University of Iowa · Iowa City, United States · NIH-11400022

• Improving Obstructive Sleep Apnea subtyping using big patient data

  Aims to use large sets of sleep and health data from adults to create better ways to classify Obstructive Sleep Apnea and predict who benefits most from treatment.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11399072

• Breathing training to lower blood pressure in sleep apnea

  A breathing training program helps people with obstructive sleep apnea lower their blood pressure by potentially calming the brain’s control of nerves that raise blood pressure.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11398204

• Personalized sleep help: real-time, at-home strategies to improve sleep and breathing problems

  A study at Northwestern University will test new real-time sleep-modulation methods at home to help people with sleep apnea and related conditions feel better and sleep more soundly.

  NIH research Northwestern University · Chicago, United States · NIH-11397518

• Home sleep testing for kids with suspected sleep apnea

  A pediatric study will test whether home sleep tests can reliably replace in-lab sleep studies for diagnosing obstructive sleep apnea in children.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11396287

• UroMarker urine test to screen obstructive sleep apnea in children

  A non-invasive urine test in kids aims to screen for obstructive sleep apnea so doctors can detect and monitor the condition more easily.

  NIH research Pgxl Technologies, LLC · Louisville, United States · NIH-11393085

• Ventilatory drive and sleep apnea: a precision approach to better treatment

  A new NIH-funded project tests whether tweaking breathing drive during sleep can prevent obstructive sleep apnea events without relying on traditional CPAP.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11392231

• The impact of sleep apnea on people taking opioid-use medications

  This project looks at whether central sleep apnea, seen in people on opioid-use disorder meds, affects sleep and treatment outcomes.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11391360

• Brain heat and chemical changes in adults with sleep apnea

  This project looks at how obstructive sleep apnea affects brain temperature and chemistry in adults, which could reveal why sleep apnea worsens thinking, mood, and health.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11391289

• Overlap of sleep apnea and COPD and its heart effects

  This grant looks at how having both COPD and sleep apnea affects the heart and whether treating sleep apnea can improve heart risk in people with overlap syndrome.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11391269

• CPAP for Sleep Apnea: How Awakening Threshold Affects Treatment

  This project looks at how a person’s tendency to wake up from breathing pauses (arousal threshold) influences how well CPAP helps with obstructive sleep apnea and related brain and heart health.

  NIH research Yale University · New Haven, United States · NIH-11387575

• Improving Heart Health Prediction and Treatment in Sleep Apnea with Advanced AI

  A new NIH grant aims to use smart AI tools to better predict heart risk and tailor CPAP treatment for people with sleep apnea using data from sleep tests.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11384496

• Engaging African American Couples to Improve CPAP Adherence for Obstructive Sleep Apnea

  A couples-based behavioral approach is being tested to help African American adults with obstructive sleep apnea use their CPAP therapy more consistently.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11383537

• Sleep apnea treatment and cognitive health in older adults

  This project looks at whether treating sleep apnea with CPAP helps protect against cognitive decline and dementia in older adults.

  NIH research University of Florida · Gainesville, United States · NIH-11382825

• Undiagnosed Obstructive Sleep Apnea in Primary Care Clinics

  A study in primary care clinics to find out how common undiagnosed obstructive sleep apnea is and who’s at risk, using existing electronic health records to spot cases.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11380949

• Time-Resolved MRI to map brain oxygen use and airway structure in sleep apnea

  A nieuwe MRI method to simultaneously map brain oxygen use and airway changes in people with obstructive sleep apnea.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11380678

• Battery-free, wirelessly powered nerve stimulator to treat sleep apnea

  A new, tiny device would stimulate a nerve in the tongue without batteries, using wireless power, to help people with obstructive sleep apnea.

  NIH research Vivamed, INC. · Santa Monica, United States · NIH-11358715

• Data-driven profiles of sleep apnea and heart health differences in a large patient group

  A study will analyze big health records and sleep data to find distinct sleep apnea types and how they relate to heart problems, especially in ways that could affect future care.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11352888

• P16 Cellular Aging and Blood Vessel Health in Sleep Apnea

  Aiming to understand how sleep apnea may speed up aging of blood vessels and raise heart disease risk, and to explore if targeting aging cells could help.

  NIH research University of Kansas Medical Center · Kansas City, United States · NIH-11350988

• REM sleep disruption and memory: how sleep fragmentation and intermittent hypoxia affect memory in sleep apnea

  This grant tests how interruptions in REM sleep from sleep apnea affect memory and brain activity in adults with obstructive sleep apnea.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11345200

• Personalized care for sleep apnea after stroke

  Uses advanced sleep testing to find the causes of sleep apnea in adults who have had a stroke so treatments can be better matched to each person.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11345168

• Improving adherence to CPAP in young adults with sleep apnea

  A plan to test two ways to help 18–25 year olds with obstructive sleep apnea stick with CPAP treatment.

  NIH research Kaiser Foundation Research Institute · Oakland, UNITED STATES · NIH-11341176

• Oxytocin Helps Sleep Apnea Patients Handle Opioid Drowsiness Better

  Aims to understand why sleep apnea makes opioids more dangerous by studying oxytocin’s role in protecting breathing, with the goal of safer pain relief for patients.

  NIH research Texas A&m University Health Science Ctr · College Station, United States · NIH-11334368

Related topics

Quick answers

How many Sleep Apnea clinical trials are recruiting right now?

34, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 15 countries. The most sites are in United States (12 trials), Canada (3 trials), China (3 trials), Spain (3 trials), France (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 5, Phase 1/2: 2, Phase 3: 2, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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