Night-to-night sleep-disordered breathing differences in women and men
Official title: Night- to-Night Variability in Sleep Disordered Breathing: Sex-Related Predictors and Impact on Obstructive Sleep Apnea Clinical Heterogeneity
Funded at University of Pittsburgh at Pittsburgh · NIH-11419262 · Data updated 2026-11-12
A study to find better biomarkers for sleep apnea severity, especially in women, by monitoring people at home for a week and tracking daily mood and energy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | September 19, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $420,557 |
| NIH project number | 5R01HL170675-03 |
| Project ID | NIH-11419262 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with suspected or diagnosed obstructive sleep apnea, especially women and those near menopausal status, who can participate in home sleep monitoring and EMA prompts.
✕Less likely to help
Individuals unable to complete home monitoring or EMA assessments may not benefit.
What this research studies
This project uses home sleep monitoring technology to collect seven nights of data from 300 participants (100 men and 200 women) across two centers. Participants will wear devices and complete multiple daily prompts about mood, energy, and stress, helping researchers see how sleep-disordered breathing varies night to night. The team will analyze new sleep-breathing metrics to see how they relate to daytime symptoms and overall mood, aiming to identify reliable markers of disease severity. Results could lead to more accurate diagnosis and better-tailored treatment for both men and women with sleep apnea.
Why it matters
Potential benefit: If successful, patients could receive more accurate diagnoses and personalized treatment plans for sleep apnea.
How similar studies have gone: Previous work suggests sex-related differences in OSA assessment; this study expands on those findings with home-based, multi-night data.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Morris, Jonna — University of Pittsburgh at Pittsburgh
- Study coordinator: Morris, Jonna
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.