Data-driven profiles of sleep apnea and heart health differences in a large patient group
Official title: Data-Driven Phenotyping of Obstructive Sleep Apnea and Sex-Specific Cardiovascular Consequences in a Multi-Modal EHR Cohort
Funded at Brigham and Women's Hospital · NIH-11352888 · Data updated 2026-11-12
A study will analyze big health records and sleep data to find distinct sleep apnea types and how they relate to heart problems, especially in ways that could affect future care.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 15, 2026 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $492,250 |
| NIH project number | 1R21HL186284-01 |
| Project ID | NIH-11352888 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with obstructive sleep apnea or suspected sleep-disordered breathing who have comprehensive EHR data and polysomnography metrics available.
✕Less likely to help
Individuals without sleep apnea or without available detailed sleep or cardiovascular data may not benefit from this research.
What this research studies
This project uses large electronic health record data from Brigham and Women’s Hospital to look beyond the standard apnea-hypopnea index. Researchers will apply unsupervised machine learning to uncover physiologic endotypes of obstructive sleep apnea, such as hypoxic burden and arousal patterns, and link them to cardiovascular outcomes over time. The goal is to improve risk stratification and identify subgroups that may benefit from targeted interventions. The study focuses on real patient data to generate clinically meaningful sleep-health insights that could guide future trials and care.
Why it matters
Potential benefit: If successful, findings could lead to more precise risk assessment and personalized treatment strategies for patients with sleep apnea and cardiovascular disease.
How similar studies have gone: Previous work supports that multi-dimensional sleep metrics relate to cardiovascular risk, but large-scale, longitudinal phenotype discovery remains limited and promising.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Redline, Susan S. — Brigham and Women's Hospital
- Study coordinator: Redline, Susan S.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.