Personalized care for sleep apnea after stroke
Official title: Towards personalized medicine: pathophysiologic contributions to post-stroke sleep apnea
Funded at University of Michigan at Ann Arbor · NIH-11345168 · Data updated 2026-11-12
Uses advanced sleep testing to find the causes of sleep apnea in adults who have had a stroke so treatments can be better matched to each person.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | April 10, 2023 |
| Project end | February 28, 2027 |
| Funding year | 2026 |
| Award (this year) | $1,369,591 |
| NIH project number | 5R01HL164755-04 |
| Project ID | NIH-11345168 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults (21+) who have had a stroke and are able to undergo overnight sleep testing and follow-up are the best fit for this work.
✕Less likely to help
People without a history of stroke, children, or anyone unable or unwilling to complete sleep studies and follow-up are unlikely to benefit directly from this project.
What this research studies
If you've had a stroke, this work looks at why sleep apnea happens afterwards by using overnight sleep studies and detailed breathing and brain-response measurements. The team will classify different underlying causes (called endotypes) such as airway collapse, muscle response, breathing-control sensitivity, and arousal patterns. They will compare these patterns across groups, including Mexican American and non-Hispanic white stroke survivors, to understand differences in severity and mechanisms. The findings would be used to guide more tailored sleep apnea treatments and follow people over time to link sleep patterns with recovery.
Why it matters
Potential benefit: Could lead to tailored sleep-apnea treatments after stroke that improve recovery and reduce disparities in outcomes.
How similar studies have gone: PSG-based endotype methods have shown promise for tailoring OSA treatments in the general population, but applying them specifically to people after stroke is relatively new.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Brown, Devin L — University of Michigan at Ann Arbor
- Study coordinator: Brown, Devin L
Related research
Other NIH-funded projects on the same topics.
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Improving sleep apnea treatment for stroke patients
This study is looking at ways to better diagnose and treat sleep apnea in veterans who have had a stroke or a mini-stroke, with the hope of helping them recover and avoid more strokes in the future.
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Understanding sleep apnea after a stroke
This study is looking at how sleep apnea affects people who have had a stroke, especially focusing on Mexican American patients, to find better ways to treat their sleep problems and improve their recovery.
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A multinational, patient-facing study tests whether hydroxyurea can safely prevent first strokes in Nigerian children with sickle cell anemia.
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This project uses popular music to help Nigerian youths and their older family members start and stick to blood pressure and stroke prevention habits.
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Determinants of Post-Stroke Cognitive Outcomes and Vascular Effects on Recovery
A large, multi-site effort aims to understand why some stroke survivors develop long-term cognitive problems and dementia, and how vascular health and pre-existing brain changes influence recovery.
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LRP1 controls NSC movement and stroke recovery
This NIH grant studies how a brain receptor called LRP1 helps neural stem cells move to stroke injuries and support recovery in adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.