Personalized care for sleep apnea after stroke
Towards personalized medicine: pathophysiologic contributions to post-stroke sleep apnea
Uses advanced sleep testing to find the causes of sleep apnea in adults who have had a stroke so treatments can be better matched to each person.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11345168 on NIH RePORTER |
What this research studies
If you've had a stroke, this work looks at why sleep apnea happens afterwards by using overnight sleep studies and detailed breathing and brain-response measurements. The team will classify different underlying causes (called endotypes) such as airway collapse, muscle response, breathing-control sensitivity, and arousal patterns. They will compare these patterns across groups, including Mexican American and non-Hispanic white stroke survivors, to understand differences in severity and mechanisms. The findings would be used to guide more tailored sleep apnea treatments and follow people over time to link sleep patterns with recovery.
Who could benefit from this research
Good fit: Adults (21+) who have had a stroke and are able to undergo overnight sleep testing and follow-up are the best fit for this work.
Not a fit: People without a history of stroke, children, or anyone unable or unwilling to complete sleep studies and follow-up are unlikely to benefit directly from this project.
Why it matters
Potential benefit: Could lead to tailored sleep-apnea treatments after stroke that improve recovery and reduce disparities in outcomes.
How similar studies have performed: PSG-based endotype methods have shown promise for tailoring OSA treatments in the general population, but applying them specifically to people after stroke is relatively new.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Brown, Devin L — University of Michigan at Ann Arbor
- Study coordinator: Brown, Devin L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.