Hypercapnia treatment for respiratory recovery in spinal cord injury patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of daily hypercapnia treatments on respiratory recovery in veterans with chronic spinal cord injuries. The researchers hypothesize that these treatments will improve respiratory symptoms and alleviate sleep apnea, which are common complications following spinal cord injuries. The pilot study will involve administering hypercapnia treatments over two weeks to assess their impact on respiratory function. The approach is based on previous findings that suggest respiratory muscle training can enhance recovery in patients with spinal cord injuries.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients with chronic SCI/D (\>6 months post-injury)
* American Spinal Injury Association (ASIA) classification A-D who have evidence of SDB (excluding those with no evidence of a neurologic deficit based on ASIA classification)
* Able-bodied patients (without SCI/D0 who have OSA.

Exclusion Criteria:

* Receiving continuous mechanical ventilation (except PAP therapy which is considered usual treatment for SDB
* Severe congestive heart failure with ejection fraction \<35%
* Recent health event that may affect sleep
* stroke
* acute myocardial infarction
* recent surgery
* hospitalization
* Alcohol or substance abuse (\<90 days sobriety)
* Self-described as too ill to engage in study procedures
* Evidence of hypercapnia on spontaneous breathing (end-tidal CO2 \>50 mmHg)
* Unable to provide self-consent for participation

Where it's running

• John D. Dingell VA Medical Center, Detroit, MI
  Detroit, Michigan, United States Recruiting

Study contacts

• Principal investigator: Abdulghani Sankari, MD PhD — John D. Dingell VA Medical Center, Detroit, MI
• Study coordinator: Abdulghani Sankari, MD PhD
• Email: Abdulghani.Sankari@va.gov
• Phone: (313) 576-1000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.