Personalized treatment for sleep apnea and its effects on Alzheimer's in Black patients
Personalized Obstructive Sleep Apnea Treatment and Effects on Alzheimer's Disease Biomarkers and Cognition Among Blacks
This study tests a personalized treatment plan for sleep apnea to see if it helps older Black patients with the condition also improve their Alzheimer's symptoms and brain health.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 330 (estimated) |
| Ages | 60 Years to 85 Years |
| Sex | All |
| Sponsor | University of Miami Academic / other |
| Locations | 1 site (Miami, Florida) |
| Trial ID | NCT06089161 on ClinicalTrials.gov |
What this trial studies
This research evaluates the effectiveness of a personalized treatment adherence model for obstructive sleep apnea (OSA) called PRAISE, aimed at improving patient compliance with the recommended Positive Airway Pressure (PAP) treatment. The study focuses on African American and Black individuals aged 60-85 who have been diagnosed with OSA. By assessing the impact of this personalized approach on Alzheimer's disease biomarkers and cognitive function, the study seeks to provide insights into the intersection of sleep apnea and cognitive health in this demographic.
Who should consider this trial
Good fit: Ideal candidates are African American, African, Caribbean, or Black individuals aged 60-85 with a diagnosis of obstructive sleep apnea.
Not a fit: Patients with progressive illnesses expected to cause disability or death within a year or those with impaired cognitive abilities may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance treatment adherence for sleep apnea, potentially improving cognitive outcomes and quality of life for patients.
How similar studies have performed: While personalized treatment approaches have shown promise in other studies, this specific focus on the intersection of sleep apnea and Alzheimer's in Black patients is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Self-reported race/ethnicity as African American, African, Caribbean or black * Ages 60-85 years * accessible by phone * OSA diagnosis * consent, including permission to release medical data Exclusion Criteria: * progressive illnesses in which disability or death is expected within 1 year * impaired cognitive/ functional ability precluding participation * intention to move within the year * and a family member currently enrolled.
Where this trial is running
Miami, Florida
- University of Miami — Miami, Florida, United States (Recruiting)
Study contacts
- Principal investigator: Girardin Jean-Louis, PhD — University of Miami
- Study coordinator: Girardin Jean-Louis, PhD
- Email: girardin.jean-louis@miami.edu
- Phone: 3052430776
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.