Oxygen therapy for kids with Down syndrome and sleep apnea

Who could benefit from this research

What this research studies

This trial will enroll hundreds of children aged 5 to 17 with Down syndrome and moderate to severe sleep apnea who did not improve after adenotonsillectomy. In two phases, researchers will first refine the study protocol with families and then randomize about 230 children to receive oxygen plus standard care versus standard care alone to see if oxygen reduces nighttime breathing problems and improves sleep. The team will monitor safety, cognitive function, heart health, sleep quality, and quality of life over time. The goal is to determine if oxygen can be a safe, effective option for managing OSA in this specific population.

Why it matters

Where this research is happening

• Cincinnati Childrens Hosp Med Ctr
  Cincinnati, United States Active

Researchers

• Principal investigator: Amin, Raouf S. — Cincinnati Childrens Hosp Med Ctr
• Study coordinator: Amin, Raouf S.

Related research

Other NIH-funded projects on the same topics.

• Personalized DISE-guided surgery for sleep apnea in children with Down syndrome

  A personalized surgical approach guided by DISE sleep-endoscopy is being tested to better treat sleep apnea in children with Down syndrome who don’t always improve after standard surgery.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11422377

• Low-flow nighttime oxygen for children and teens with Down syndrome and sleep apnea

  This project tests whether nightly low-flow oxygen helps children and adolescents with Down syndrome who have moderate to severe obstructive sleep apnea.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11193933

• Medications to treat sleep apnea and boost thinking in children with Down syndrome

  This project gives a combination of two commonly used medicines, atomoxetine and oxybutynin, to children with Down syndrome who have obstructive sleep apnea to see if it helps them sleep better and think more clearly.

  NIH research University of Arizona · Tucson, United States · NIH-11178895

• Testing oxygen therapy for children with Down Syndrome and sleep apnea

  This study is looking at whether low-flow oxygen therapy can help kids and teens with Down Syndrome who have trouble breathing while sleeping, aiming to see if it can make them feel better and improve their daily lives, especially for those who haven't found relief with other treatments.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-10972922

• Personalized surgery for sleep apnea in children with Down syndrome

  This trial will see if using sleep endoscopy to guide personalized airway surgery helps children with Down syndrome who have obstructive sleep apnea.

  NIH research Oregon Health & Science University · Portland, United States · NIH-10972917

• Using positive airway pressure to treat sleep apnea in children with Down syndrome

  This study is looking at how well a special breathing machine called PAP therapy helps kids with Down syndrome and sleep apnea, by comparing a six-month hands-on support program to regular care, to see which helps them stick with the treatment better and feel better overall.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-10912150

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.