Investigating treatments for sleep apnea in elderly veterans

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to explore the effectiveness of oxygen, finasteride, and acetazolamide in reducing sleep apnea among elderly veterans. It focuses on understanding how these interventions can modulate breathing stability during sleep by affecting ventilatory control mechanisms. The research will compare cerebrovascular reactivity between younger and older adults to identify key factors contributing to sleep apnea in the elderly. Ultimately, the goal is to develop novel therapies that improve the quality of life for elderly veterans suffering from sleep-disordered breathing.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults with mild to moderate sleep apnea with Apnea-Hypopnea Index (AHI)\>/=5 to 20/hour with central, obstructive, mixed apneas and hypopneas
* For the finasteride protocol elderly men with above criteria will be enrolled

Exclusion Criteria:

* Patients with severe sleep apnea (Apnea-Hypopnea Index (AHI)\>20/hour)
* Patients with history of prostate cancer
* Males with hypogonadism
* History of cardiac disease, including myocardial infarction
* Bypass surgery
* Atrial and ventricular tachy-bradycardias
* Systolic congestive heart failure and Cheyne-Stokes respiration
* Current unstable angina
* Stroke
* Schizophrenia
* Untreated hypothyroidism
* Seizure disorder
* Preexisting renal failure and liver disorders
* Failure to give informed consent.
* Patients with significant pulmonary diseases by history and abnormal pulmonary function testing, including moderate obstructive/restrictive lung/chest wall disorders with resting oxygen saturation of \<96% or on supplemental oxygen
* Patients on certain medications including:

  * study drugs
  * sympathomimetics/parasympathomimetics or their respective blockers
  * narcotics
  * antidepressants
  * anti-psychotic agents
  * other central nervous system (CNS) altering medications
  * current alcohol, tobacco or recreational drug use
* Patients with Body mass index (BMI)\>34 kilograms per square meter (kg/m2) will be excluded to avoid the effects of morbid obesity on pulmonary mechanics and ventilatory control
* Elderly with unstable gait or mobility issues that may preclude safe participation
* Individuals with allergy to finasteride or acetazolamide will be excluded from the specific protocol
* Pregnant women

Where it's running

• John D. Dingell VA Medical Center, Detroit, MI
  Detroit, Michigan, United States Recruiting

Study contacts

• Principal investigator: Susmita Chowdhuri, MD MS — John D. Dingell VA Medical Center, Detroit, MI
• Study coordinator: Ruchi Rastogi, MS
• Email: ruchi.rastogi@va.gov
• Phone: (313) 576-4464

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Neurostimulation treatment for sleep-disordered breathing

  This trial will test whether the Lunair Alpha System, a small implanted neurostimulator, can reduce breathing problems during sleep for people with moderate to severe sleep apnea who cannot tolerate or access other treatments.

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• IBI362 for Chinese adults with obstructive sleep apnea and BMI ≥28

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• Neurostimulation treatment for sleep apnea

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  Recruiting Lunair Medical · Asunción, Paraguay · NCT06883617

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.