Treatment for sleep apnea in patients with cervical spinal cord injuries

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates therapeutic approaches for sleep-disordered breathing in patients with chronic cervical spinal cord injuries. It aims to understand the causes of central sleep apnea and its relationship with upper airway obstruction. The research will test the effects of acute episodic hypoxia and supplemental oxygen on respiratory events during sleep. The ultimate goal is to identify strategies that can improve the quality of life for these patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. healthy adults between the ages of 18 - 89
2. chronic spinal cord injury patients (T6 and above), \> 3 months since injury and not on mechanical ventilation, and have not received mechanical ventilation via tracheostomy in the past.

Exclusion Criteria:

1. subjects ≤ 17 yrs old
2. Pregnant and lactating females
3. History of head trauma that resulted in neurological symptoms or loss of consciousness
4. advanced heart, lung, metabolic, liver or chronic kidney disease.
5. severe obstructive or restrictive respiratory defect by PFTs or history of tracheostomy
6. extreme obesity defined for this protocol as BMI ≥ 40 kg/m2 (to avoid the effect of morbid obesity on ventilation).

Where it's running

• John D. Dingell VA Medical Center
  Detroit, Michigan, United States Recruiting

Study contacts

• Principal investigator: M Safwan Badr, M.D. — John D. Dingell VA Medical Center
• Study coordinator: M Safwan Badr, M.D.
• Email: m.badr@va.gov
• Phone: 313-576-3548

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.