Condition

Cardiometabolic Diseases clinical trials and research

• 15Clinical trials
• 20NIH research projects
• 2New in 30 days
• 7Countries

Newest Cardiometabolic Diseases clinical trials

All recruiting trials (15)

• Differentiating heart disease in autoimmune vs. type 2 diabetes

  This study tests whether adult-onset autoimmune diabetes (AID/LADA) and type 2 diabetes (T2D) differ in how diabetic heart disease develops, using advanced heart imaging in people with AID, T2D, and healthy controls.

  Recruiting University of Roma La Sapienza · Rome, Roma · NCT07911007

• Cardio-Metabolic Clinic care for adults with type 2 diabetes and cardiovascular disease

  This trial tests whether a specialized Cardio-Metabolic Clinic can improve heart function and overall health for adults with type 2 diabetes and cardiovascular disease compared with usual care.

  Recruiting Odense University Hospital · Svendborg · NCT07878325

• A safe test of a new medicine for healthy adults

  This study tests a new medicine called NNC0705-0002 in healthy adults to see if it is safe and how it behaves in the body.

  Recruiting Phase 1 Novo Nordisk A/S · Groningen · NCT07797855

• Nutrition Counselling for people with diabetes and high blood pressure

  Aimed at adults with both type 2 diabetes and hypertension, this study tests whether structured nutrition counselling helps people stick to better diets and improve health-related quality of life.

  Recruiting Bahir Dar University · Dessie · NCT07712900

• Maternal insulin and fat metabolism in pregnancies at risk for preeclampsia and gestational diabetes

  This project will try to see if insulin resistance and how the body burns fats early in pregnancy predict later preeclampsia or gestational diabetes in people at higher risk.

  Recruiting University of Tennessee Graduate School of Medicine · Knoxville, Tennessee · NCT07565727

• SMILE: Tracking muscle loss, metabolic health, and aging over time

  This project will follow adults to see if combining clinical data, imaging, and blood/tissue samples can detect and track muscle loss and metabolic changes linked to aging.

  Recruiting RenJi Hospital · Shanghai · NCT07205510

• Sustainable diets to improve heart and metabolic health

  This tests whether following a Planetary Health Diet or an ovo-lacto-vegetarian diet, compared with a general healthy diet, improves metabolic health in adults aged 45–70 who are at higher risk for heart disease.

  Recruiting University of Copenhagen · Copenhagen, Copenhagen · NCT07189676

• Health Chat for lifestyle planning in people with multiple cardiometabolic conditions

  This program tests whether a 12-week face-to-face and WeChat-based Health Chat can help adults with two or more cardiometabolic conditions improve lifestyle habits and health.

  Recruiting at 3 sites The University of Hong Kong · Suzhou, Jiangsu and 2 other locations · NCT07158697

• Earplugs to reduce noise-related heart and metabolic risk

  This study will test whether wearing noise-canceling earplugs reduces stress-related brain activity and other heart-risk markers in adults with atherosclerosis or common cardiovascular risk factors who are bothered by transportation noise.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT07148817

• Real-world cardiometabolic protection outcomes

  This project will test whether common cardiometabolic risk factors predict death and major heart-related events in adults with hypertension, diabetes, obesity, dyslipidemia, or high uric acid.

  Recruiting Sun Yat-sen University · Guangzhou, Guangdong · NCT07038083

• Preventive screening and health coaching for people facing food insecurity

  A health coaching program delivered virtually is being tested to see if it lowers heart-disease risk and improves blood pressure, cholesterol, and diabetes markers in low-income adults who have limited access to food and healthcare.

  Recruiting Rush University Medical Center · Chicago, Illinois · NCT06907524

• Understanding the relationship between sleep disordered breathing and multiple health conditions

  This study is trying to see how sleep problems affect people's overall health and quality of life by looking at different health conditions in patients with sleep disordered breathing.

  Recruiting Xiangya Hospital of Central South University · Changsha · NCT06755840

• Heart failure prevention for patients with type 2 diabetes

  This study tests a new way to help people with type 2 diabetes avoid heart failure by using risk scores and alerts for their doctors to provide better care.

  Recruiting at 3 sites University of Texas Southwestern Medical Center · Dallas, Texas and 2 other locations · NCT06593327

• Investigating how maternal health affects childhood obesity and cardiometabolic disorders

  This study looks at how a mother's health during pregnancy affects her child's risk of obesity and heart problems as they grow up.

  Recruiting Helsinki University Central Hospital · Helsinki · NCT05223530

• Genotype-guided approach to improve cardiometabolic health using natriuretic peptides

  This study is testing if a special approach using natriuretic peptides can help improve heart and metabolic health in adults with a certain genetic variant that leads to lower levels of these peptides.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT05216042

NIH-funded research (20)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Cardiometabolic Health in World Trade Center Responders and How Exposures Help Shape It

  This project looks at how surviving the World Trade Center cleanup exposure might influence long-term heart and metabolic health in responders.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11480112

• Food is Medicine programs to improve diet and reduce cardiometabolic diseases

  A health study from Tufts University is testing how adding medically tailored meals and food-based prescriptions within healthcare can improve diet and lower cardiometabolic disease risk.

  NIH research Tufts University Boston · Boston, United States · NIH-11408445

• Tulane program to accelerate clinical research on heart and metabolic diseases

  A funded program at Tulane supports teams researching heart and metabolic diseases to speed up translating discoveries into better patient care.

  NIH research Tulane University of Louisiana · New Orleans, United States · NIH-11379470

• Gut microbiome and heart/metabolic disease influence

  A large NIH grant is exploring how gut bacteria affect common heart and metabolic diseases and how we might use that knowledge to improve health.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11335422

• Fat-linked amino acids and fatty liver with heart disease risk

  This work looks at whether changes in fat-linked amino acids made in the liver are tied to fatty liver disease and a higher risk of clogged arteries.

  NIH research Louisiana State Univ Hsc Shreveport · Shreveport, United States · NIH-11324547

• Macrophage roles in heart disease and fat-related conditions

  A multi-project program looks at how immune cells called macrophages contribute to heart disease, obesity, and fatty liver, with the aim of finding new ways to prevent and treat these conditions.

  NIH research New York University School of Medicine · New York, United States · NIH-11323529

• Gut Microbes, Aging, and Heart Health in American Indians

  This project looks at how the tiny living things in our gut, called the gut microbiome, might be connected to aging and heart-related conditions like diabetes and high blood pressure in American Indian communities.

  NIH research University of South Florida · Tampa, United States · NIH-11321466

• How cholesterol-related molecules drive inflammation in heart and metabolic disease

  This project will try changing a cholesterol-making enzyme in immune and liver cells to reduce artery-clogging inflammation in people with atherosclerosis and other cardiometabolic conditions.

  NIH research Yale University · New Haven, United States · NIH-11247058

• Using genetics to personalize risk and find existing medicines for type 2 diabetes and fatty liver

  Researchers will use genetic and medical-record data to spot people at higher risk for type 2 diabetes and non-alcoholic fatty liver disease and to identify existing medicines that might help them.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11240328

• Heart and diabetes risks after 9/11 exposure in World Trade Center responders

  This project looks at whether people who worked, lived, or cleaned up near the World Trade Center after 9/11 have higher chances of heart disease and diabetes.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11222288

• Medically tailored meals and produce prescriptions to prevent diabetes and heart disease

  Seeing if medically tailored meals and produce prescriptions help adults with or at risk for diabetes and heart disease eat healthier, improve health, and lower medical costs.

  NIH research Tufts University Boston · Boston, United States · NIH-11180480

• Investigating how oxalate metabolism affects heart and liver diseases

  This study is looking at how the way your body processes oxalate might be connected to nonalcoholic fatty liver disease and heart problems, and it hopes to find new ways to help improve your health by understanding these links better.

  NIH research Louisiana State Univ Hsc Shreveport · Shreveport, United States · NIH-11095882

• Identifying subtypes and mechanisms of cardiometabolic diseases using multi-omics data

  This study is looking at why some people who are obese don’t develop health problems related to their weight, and it’s for anyone interested in understanding how different factors like genes and proteins can affect their risk for heart and metabolic issues; by sharing some health information and samples, you can help r

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11080249

• Investigating lipidated amino acids in heart and liver diseases

  This study is looking at how certain fatty-linked amino acids affect liver health and heart disease, with the goal of finding new ways to help people with non-alcoholic fatty liver disease and related heart issues, and it may involve patients sharing samples or information to help with the research.

  NIH research Louisiana State Univ Hsc Shreveport · Shreveport, United States · NIH-11058494

• How cholesterol regulation affects immune responses in heart diseases

  This study is looking at how changes in cholesterol levels can affect the immune system and contribute to heart diseases like atherosclerosis, and it aims to find new ways to help improve heart health by understanding these connections better.

  NIH research Yale University · New Haven, United States · NIH-11029401

• Using genetics to find new treatments for diabetes and liver disease

  This study is looking at how our genes might play a role in type 2 diabetes and fatty liver disease to help doctors predict who might be at risk and find new treatments, especially since there aren’t any approved medicines for fatty liver disease yet.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11005740

• Exploring the role of lipids and mitochondria in heart and metabolic diseases

  The 2024 Kern Lipid Conference is a friendly gathering for scientists to talk about how fats in our bodies and tiny energy factories called mitochondria affect health issues like obesity, diabetes, and heart disease, with the goal of inspiring new researchers and encouraging teamwork in understanding these important to

  NIH research Washington University · Saint Louis, United States · NIH-11000581

• Investigating long-term health effects of 9/11 exposure on heart and metabolic diseases

  This study is looking at how breathing in toxic dust and chemicals from the World Trade Center after 9/11 has impacted the long-term health of first responders and cleanup workers, especially in relation to heart and diabetes issues, to help improve healthcare for those affected.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-10954249

• Understanding genetic risks for heart and metabolic diseases in diverse populations

  This study is looking at how our genes might affect the risk of heart disease and type 2 diabetes, especially in people from different backgrounds, to help create better ways to predict and prevent these conditions for everyone.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-10924035

• The role of gut bacteria in heart and metabolic diseases

  This study is looking at how the bacteria in our gut can affect heart health and metabolism, and it's for anyone interested in understanding how these tiny organisms might help improve conditions like heart disease.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-10653038

Related topics

Quick answers

How many Cardiometabolic Diseases clinical trials are recruiting right now?

15, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in United States (5 trials), China (4 trials), Denmark (2 trials), Ethiopia (1 trial), Netherlands (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →