Effects of CPAP on cholesterol and uric acid levels in patients with sleep apnea and high cholesterol

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the impact of 12 months of continuous positive airway pressure (CPAP) treatment combined with standard pharmacological therapy on the lipid profiles and serum uric acid levels in patients suffering from moderate to severe obstructive sleep apnea and dyslipidemia. The study aims to assess not only improvements in lipid profiles but also the effects on insulin resistance, cardiovascular risk, glycemic control, and inflammation markers. Participants will receive hygienic-dietary recommendations and be encouraged to engage in daily physical activity as part of their treatment regimen.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Subjects from 35 to 80 years old
* Diagnosis of dyslipidemia. It will be considered as such, the existence of a previous clinical record of a diagnosis of dyslipidemia associated with treatment with lipidlowering agents, treatment with lipid-lowering agents or the presence of an altered blood test in the last two months, using the following cut-off points: total cholesterol ≥ 200 mg/dl, triglycerides ≥ 180 mg/dl, HDL-cholesterol ≤ 40 mg/dl or LDL-cholesterol ≥ 150 mg/dl.
* Moderate-severe sleep apnea, defined by AHI \> 15 h-1 .

Exclusion Criteria:

* Predominance of central apneas-hypopneas, defined as more than 25% of total respiratory events.
* Patients with indications for CPAP treatment according to the International Sleep Consensus: hypertensive, excessive daytime sleepiness (Epworth Sleepiness Scale \> 11) or impaired sleep-related quality of life considered relevant by their regular physician.
* Professional drivers, at-risk profession or respiratory insufficiency (according to criteria of the clinical pathway for the diagnosis and treatment of sleep-disordered breathing).
* Pretreatment with CPAP

Where it's running

• Hospital Universitario del Henares
  Coslada, Madrid, Spain Recruiting

Study contacts

• Principal investigator: Ana De la Rocha Prieto, MD — Hospital Universitario del Henares
• Study coordinator: Francisco Garcia-Rio, MD
• Email: fgr01m@gmail.com
• Phone: +34639911718

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.