Program to reduce blood pressure in sleep apnea patients with resistant hypertension
Official title: Comparison of Standard Treatment by Continuous Positive Airway Pressure (CPAP) and CPAP Combined to a Physical Activity Program for Reducing Blood Pressure in Sleep Apnea Patients With Resistant Hypertension: RAP Randomized Controlled Trial
Run by AGIR à Dom · NCT02057783 · Data updated 2026-11-12
This study is testing if a physical activity program combined with CPAP treatment can help people with sleep apnea and high blood pressure better control their blood pressure throughout the day.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | AGIR à Dom Academic / other |
| Locations | 5 sites (Québec and 4 other locations) |
| Status | Recruiting |
| Started | March 26, 2015 |
| Main results expected | February 18, 2025 |
| Study ends | February 18, 2025 |
| Registry record updated | February 20, 2025 |
| Trial ID | NCT02057783 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include patients diagnosed with obstructive sleep apnea and resistant hypertension who are not adequately controlled by three or more antihypertensive medications.
✕Probably not a fit
Patients with acute hypertension or contraindications to CPAP treatment may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effectiveness of a physical activity program combined with CPAP treatment for patients suffering from obstructive sleep apnea syndrome (OSAS) and resistant hypertension. The hypothesis is that this combined approach will enhance 24-hour blood pressure control in these patients. Previous smaller studies have indicated that CPAP can significantly lower blood pressure during waking hours, and this study aims to build on that evidence with a larger sample size. Participants will be monitored for changes in blood pressure as they engage in the physical activity program alongside their CPAP treatment.
Why it matters
Potential benefit: If successful, this program could significantly improve blood pressure management in patients with resistant hypertension related to sleep apnea.
How similar studies have gone: Previous studies, including the HIPARCO study, have shown promising results in using CPAP for blood pressure reduction in similar patient populations.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient with an obstructive sleep apnea (apnea-hypopnea index \> or equal to 15) * Patient with resistant hypertension uncontrolled by 3 or more antihypertensive agents * Ambulatory patient Exclusion Criteria: * Acute hepatic failure, biliary cirrhosis, cholestasis * Acute hypertension (SBP\>= 180 mmHg and/or DBP \>= 110 mmHg) * Contraindication to CPAP treatment
Where it's running
-
Institut Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ)
Québec, Canada Recruiting -
Hopital Universitaire de Grenoble
La Tronche, France Recruiting -
Clinique Pasteur
Toulouse, France Recruiting -
Hopitaux Universitaires de Genève
Geneva, Switzerland Withdrawn -
Centre Hospitalier Universitaire Vaudois
Lausanne, Switzerland Withdrawn
Study contacts
- Principal investigator: Jean-Louis Pépin, Pr MD PhD — Laboratoire EFCR, CHU de Grenoble, 38043, Grenoble, France
- Study coordinator: Jean-Louis Pépin, Pr MD PhD
- Email: JPepin@chu-grenoble.fr
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.