Condition

Graft Failure clinical trials and research

• 12Clinical trials
• 10NIH research projects
• 7Countries

Newest Graft Failure clinical trials

All recruiting trials (12)

• Differences in Outcomes After Allograft vs Autograft in Revision ACL Repair

  This study looks at whether using donor tissue (allograft) versus the patient’s own tissue (autograft) in revision ACL surgery leads to different results.

  Recruiting Istituto Ortopedico Rizzoli · Bologna, Bologna · NCT07671235

• Ruxolitinib-enhanced haploidentical transplant for children and young adults with sickle cell disease

  This trial will test whether adding ruxolitinib to a reduced-intensity haploidentical transplant lowers the risk of graft failure in children and young adults with sickle cell disease.

  Recruiting Phase 1/2 Arkansas Children's Hospital Research Institute · Aurora, Colorado and 3 other locations · NCT07252050

• Preventing graft rejection after allogeneic stem cell transplant

  This trial will try the drug emapalumab to see if it can prevent graft rejection in people judged high risk after allogeneic hematopoietic stem cell transplant.

  Recruiting Early Phase 1 Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT07244419

• Donor transplant for high risk blood disorders

  This study is testing if a stem cell transplant from a matched sibling can help people with high-risk blood disorders like sickle cell disease and thalassemia feel better.

  Recruiting Phase 2 Masonic Cancer Center, University of Minnesota · Minneapolis, Minnesota · NCT06872333

• Investigating graft failure after heart bypass surgery

  This study looks at why heart bypass grafts fail by using special scans and tests on people who have had the surgery and those who might have problems with their grafts.

  Recruiting University of Edinburgh · Edinburgh, Midlothian · NCT06800430

• Comparing immunosuppression strategies in patients with late renal graft failure

  This study is testing whether continuing low-dose immunosuppression or stopping it after six months is better for people with late kidney transplant failure.

  Recruiting Phase 4 Hospital Universitari Vall d'Hebron Research Institute · Barcelona · NCT06676696

• Using CD34+ Selected Stem Cells to Treat Graft Failure

  This study is testing if using special stem cells can help people who have had a stem cell transplant and are experiencing problems with their graft.

  Recruiting NYU Langone Health · New York, New York · NCT06569082

• Modified second transplantation for patients with graft failure

  This study is testing a new approach to a second stem cell transplant for patients who didn't fully recover after their first transplant to see if it helps them get better, especially with their platelet counts.

  Recruiting Peking University People's Hospital · Beijing, Beijing Municipality · NCT06512545

• Second haploidentical stem cell transplantation for graft failure

  This study is testing if a second stem cell transplant from a partially matched donor can help patients with blood cancers who had problems with their first transplant.

  Recruiting Peking University People's Hospital · Beijing, Beijing Municipality · NCT06512519

• One-year comparison of radial artery versus no-touch saphenous vein grafts in women having coronary bypass surgery

  This test compares whether a radial artery graft or a 'no-touch' saphenous vein graft stays open better for one year in women undergoing coronary bypass surgery.

  Recruiting University of Sao Paulo General Hospital · São Paulo, São Paulo · NCT06179329

• Using donor-derived DNA and immune cells to predict kidney transplant rejection

  This study is testing if measuring certain DNA and immune cells from kidney donors can help predict if a kidney transplant will be rejected by the recipient's body.

  Recruiting Loma Linda University · Loma Linda, California · NCT05084768

• Evaluating heart patients with previous bypass surgery for graft issues and heart disease progression

  This study is trying to see how heart patients who had bypass surgery and are having chest pain again are doing over time, especially looking at issues with their grafts and heart disease.

  Recruiting Amsterdam UMC, location VUmc · Amsterdam · NCT04772768

NIH-funded research (10)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Targeted NAD+ Replenishment to Protect Vein Grafts After Bypass

  Aims to protect vein grafts used in bypass surgery by delivering NAD+ directly to vascular cells to reduce failure from aging and injury.

  NIH research Northwestern University · Chicago, United States · NIH-11433243

• Gene therapy to protect vein grafts after bypass surgery

  Testing a gene therapy meant to help veins used in bypass operations stay open longer for people with coronary or peripheral artery disease.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11293427

• Targeted gene therapy to protect prosthetic leg bypass grafts

  This project uses targeted gene-silencing treatments to prevent narrowing and failure of synthetic bypass grafts in people with blocked leg arteries.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11251803

• Improving vein graft success after heart bypass surgery

  This project uses computer models to design better ways to prevent vein grafts from failing after coronary artery bypass surgery.

  NIH research Stanford University · Stanford, United States · NIH-11117074

• Gene therapies to prevent vein graft failure in heart and leg surgeries

  This study is looking at a new way to help improve the success of vein grafts used in heart and leg surgeries, especially for people with coronary artery disease and peripheral arterial disease, by using a special gene therapy that could help keep the grafts healthy and working better for longer.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11094828

• Understanding why transplanted hearts fail over time

  This study is looking at how heart transplants can sometimes fail over time, especially when the heart muscle gets too thick, and it aims to understand the different types of cells involved in this process to help improve the health and longevity of transplanted hearts for patients.

  NIH research Northwestern University at Chicago · Chicago, United States · NIH-11060859

• Gene therapies to prevent failure of prosthetic bypass grafts

  This study is looking at a new way to help people with severe leg artery blockages by using a special treatment to improve the success of prosthetic grafts, which can sometimes fail and lead to serious problems like losing a limb.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11028761

• Using computer models to improve vein graft success after heart surgery

  This study is looking for ways to help heart surgery patients by finding out how special coverings can keep vein grafts from failing after surgery, making the recovery process smoother and more successful.

  NIH research Stanford University · Stanford, United States · NIH-10895578

• Using imaging and blood tests to predict transplant failure after stem cell transplants

  This study is looking at new ways to spot early signs of graft failure in patients who have had a stem cell transplant, using special imaging and blood tests to help doctors catch problems sooner and provide better care, especially for those getting cord blood or family donor transplants.

  NIH research Emory University · Atlanta, United States · NIH-10672998

• Using a 3D printed device to prevent vein graft failure after heart surgery

  This study is testing a new biodegradable device that helps keep vein grafts working well after heart surgery, aiming to help many patients avoid complications and improve their recovery.

  NIH research Biograft, INC. · Stanford, United States · NIH-10385132

Related topics

Quick answers

How many Graft Failure clinical trials are recruiting right now?

12, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in United States (5 trials), China (2 trials), Italy (1 trial), Brazil (1 trial), Netherlands (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 1, Phase 2: 1, Early Phase 1: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →