Accelerating hydroxyurea use for sickle cell disease in Nigeria
Official title: mAnaging siCkle CELl disease through incReased AdopTion of hydroxyurEa in Nigeria (ACCELERATE)
Funded at New York University · NIH-11601755 · Data updated 2026-11-12
A pragmatic study in Nigeria aims to help doctors use hydroxyurea more consistently for people with sickle cell disease.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 15, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $227,383 |
| NIH project number | 3U01HL168084-04S1 |
| Project ID | NIH-11601755 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with sickle cell disease in Nigeria (and similar settings) who are eligible for hydroxyurea and receive care in participating facilities.
✕Less likely to help
Patients in settings not included in the study, or those with contraindications to hydroxyurea, may not benefit.
What this research studies
This project tests practical strategies to help healthcare providers prescribe hydroxyurea more often to patients with sickle cell disease in Nigeria, where many eligible people do not receive it. It uses real-world clinical settings to identify barriers like training gaps and limited support, then implements solutions that can be scaled to other communities with limited access to specialists. The goal is to increase adoption and sustained delivery of hydroxyurea to reduce pain crises, hospital visits, and mortality. While based in Nigeria, the findings could also inform care improvements in rural or under-resourced areas in the United States.
Why it matters
Potential benefit: If successful, patients with sickle cell disease could experience fewer painful episodes, fewer hospitalizations, and improved survival through broader use of hydroxyurea.
How similar studies have gone: Previous evidence shows hydroxyurea is effective; this study focuses on implementation, an area with demonstrated but variable success in real-world settings.
Where this research is happening
-
New York University
New York, United States Active
Researchers
- Principal investigator: Peprah, Emmanuel K — New York University
- Study coordinator: Peprah, Emmanuel K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.