Telehealth intervention to help adolescents with sickle cell disease transition to adult care
Official title: The Cognitive-Remediation of Executive and Adaptive Deficits in Youth (C-READY) Intervention: A Randomized Controlled Trial for Adolescents With Sickle Cell Disease to Prepare for Transition of Care
Run by University of Alabama at Birmingham · NCT05336201 · Data updated 2026-11-12
This study is testing a telehealth program to help teenagers with sickle cell disease improve their thinking skills and self-care as they transition to adult healthcare.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Ages | 10 Years to 18 Years |
| Sex | All |
| Enrollment | 120 (estimated) |
| Sponsor | University of Alabama at Birmingham Academic / other |
| Locations | 1 site (Birmingham, Alabama) |
| Status | Recruiting |
| Started | July 1, 2022 |
| Main results expected | September 30, 2026 |
| Study ends | June 30, 2027 |
| Registry record updated | February 27, 2026 |
| Trial ID | NCT05336201 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adolescents aged 10-18 diagnosed with sickle cell disease who are actively followed at Children's of Alabama Hospital and are English-speaking.
✕Probably not a fit
Patients with a history of seizures, overt stroke, intellectual disability, autism spectrum disorder, or those currently on psychotropic medications may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study tests the effectiveness of a telehealth version of the Cognitive-Remediation of Executive and Adaptive Deficits in Youth (C-READY) intervention aimed at adolescents with sickle cell disease (SCD). The intervention focuses on improving cognitive skills and self-management abilities over four weeks through eight one-on-one telehealth sessions with a trained therapist. Caregivers are also involved through weekly phone sessions to enhance accountability and support. The goal is to facilitate a smoother transition to adult self-care for youth facing cognitive challenges due to SCD.
Why it matters
Potential benefit: If successful, this intervention could significantly improve self-efficacy and self-care skills in adolescents with sickle cell disease, aiding their transition to adulthood.
How similar studies have gone: While cognitive remediation interventions have been explored in various contexts, this specific telehealth adaptation for adolescents with sickle cell disease is a novel approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of SCD (all genotypes) * Active follow-up at Children's of Alabama Hospital * Ages 10-18 * English-speaking Exclusion Criteria: * History of seizures or overt stroke * History of Intellectual Disability or Autism Spectrum Disorder * Inability to participate in the MRI scan, such as metal implants, neurostimulators, claustrophobia * Currently on psychotropic medications
Where it's running
-
University of Alabama at Birmingham
Birmingham, Alabama, United States Recruiting
Study contacts
- Study coordinator: Donna Murdaugh, PhD
- Email: donnamurdaugh@uabmc.edu
- Phone: 2056382189
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.