Investigation of genetics related to blood diseases
Official title: Investigation of the Genetics of Hematologic Diseases
Run by St. Jude Children's Research Hospital · NCT02720679 · Data updated 2026-11-12
This study is trying to understand the genetics behind blood diseases by collecting samples and health information from people with these conditions and their family members.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 1716 (estimated) |
| Sponsor | St. Jude Children's Research Hospital Academic / other |
| Locations | 1 site (Memphis, Tennessee) |
| Status | Recruiting |
| Started | June 17, 2016 |
| Main results expected | July 2040 |
| Study ends | July 2050 |
| Registry record updated | June 9, 2026 |
| Trial ID | NCT02720679 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals receiving therapy for non-malignant hematologic disorders and their biologically related family members.
✕Probably not a fit
Patients without a non-malignant hematologic disorder or those not related to a proband may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to collect and store biological samples and health information to enhance understanding of the causes and treatments of blood diseases. It focuses on individuals with non-malignant hematologic disorders and their biologically related family members. By utilizing advanced genomic techniques, the study seeks to identify genetic mutations and modifiers associated with these conditions. Participants will provide blood samples and undergo thorough medical history assessments, with annual follow-ups for updates on their health and family history.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with blood diseases.
How similar studies have gone: Other studies utilizing genomic approaches in hematology have shown promise, indicating potential for success in this area.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * An individual (proband) receiving therapy or expert consultation regarding a non-malignant hematologic disorder, MDS or MPN. * A biologically-related individual to the identified proband to include: first, second or third degree relatives. Exclusion Criteria: * None
Where it's running
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St. Jude Children's Research Hospital
Memphis, Tennessee, United States Recruiting
Study contacts
- Principal investigator: Marcin Wlodarski, MD, PhD — St. Jude Children's Research Hospital
- Study coordinator: Marcin Wlodarski, MD, PhD
- Email: referralinfo@stjude.org
- Phone: 888-226-4343
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Transplantation for inherited bone marrow failure disorders
This study is testing a new way to do stem cell transplants for people with inherited bone marrow failure disorders to see if it can help them recover faster and reduce the risk of infections without needing extra medication.
-
Investigating genetic factors in childhood cancer
This study is trying to find out if certain genes passed down in families can increase the risk of childhood cancer by looking at samples from kids who have had cancer and their relatives.
-
Understanding cancer risks in inherited bone marrow failure syndromes
This study is trying to understand the cancer risks in people with inherited bone marrow failure syndromes to help improve screening and prevention for families at risk.
-
Understanding congenital bone marrow failure and related disorders through a national network
This project tests whether people with rare inherited bone marrow failure syndromes or related conditions really have the underlying genetic causes, by collecting data and samples across multiple centers.
-
Reduced intensity bone marrow transplant for immune and bone marrow disorders
This study is testing a gentler type of bone marrow transplant to see if it can help people with immune and bone marrow disorders recover better and live longer.
-
Stem cell transplantation for blood disorders using specific cell depletion techniques
This study is testing a new way of using stem cell transplants for children and young adults with blood disorders to see if removing certain cells helps them recover better and improve their quality of life.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.