MAP SCD: How place-based factors affect sickle cell disease
Official title: MAP SCD: Mechanisms for Actionable Place-Based Drivers of Health in Sickle Cell Disease
Funded at Icahn School of Medicine at Mount Sinai · NIH-11449158 · Data updated 2026-11-12
A study to understand how where people live and their daily environment influence the illness and pain in sickle cell disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 15, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $850,669 |
| NIH project number | 1R01HL183586-01A1 |
| Project ID | NIH-11449158 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals living with sickle cell disease who have contributed samples to the SSCC biorepository and are connected to the Sinai Sickle Cell Collaborative.
✕Less likely to help
Patients not represented in the SSCC biorepository or not engaged with the participating communities may not directly benefit.
What this research studies
This project looks at how neighborhood stressors, food access, temperature, air pollution, and housing affect inflammation and organ damage in people with sickle cell disease. Researchers will use a biorepository of samples from long-standing studies to identify biological pathways that link place-based exposures to disease activity. The work combines environmental data with biological analyses to map which factors most strongly influence symptoms, complications, and health care needs. Findings could point to new ways to prevent organ damage and reduce pain for patients. The study is grounded in community-engaged research and uses existing samples from the Sinai Sickle Cell Collaborative.
Why it matters
Potential benefit: If successful, the work could lead to targeted interventions and policies to reduce exposure-related health risks for people with sickle cell disease.
How similar studies have gone: Prior similar research has linked neighborhood factors to health outcomes in chronic diseases, suggesting potential for meaningful findings in SCD.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Mccuskee, Sarah — Icahn School of Medicine at Mount Sinai
- Study coordinator: Mccuskee, Sarah
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.