Using virtual reality to help manage pain in sickle cell disease patients

Pilot Study to Investigate the Use of Virtual Reality Devices as an Adjunct to Usual Care for Patients With Sickle Cell Disease Experiencing Vaso-Occlusive Crises

NA · University of Maryland, Baltimore · NCT06184126

This study is testing if using virtual reality can help adults with sickle cell disease feel less pain during painful episodes.

Quick facts

PhaseNA
Study typeInterventional
Enrollment30 (estimated)
Ages18 Years and up
SexAll
SponsorUniversity of Maryland, Baltimore (other)
Locations1 site (Baltimore, Maryland)
Trial IDNCT06184126 on ClinicalTrials.gov

What this trial studies

This study evaluates the effectiveness of virtual reality as an additional treatment for patients with sickle cell disease who are experiencing vaso-occlusive crises. Conducted at the University of Maryland Medical Center, the trial involves enrolling adult patients who meet specific criteria and assessing their pain levels before, during, and after the use of virtual reality devices. Participants will engage with the virtual reality equipment for up to two hours while their pain intensity is measured at four different timepoints. The goal is to determine if virtual reality can provide significant pain relief in conjunction with standard care.

Who should consider this trial

Good fit: Ideal candidates are adults over 18 years old with a history of sickle cell disease presenting to the emergency department due to acute pain from vaso-occlusive crises.

Not a fit: Patients with complicated crises, those not receiving intravenous opioids, or individuals with certain medical conditions that prevent the use of virtual reality will not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could offer a novel, non-pharmacological method to alleviate pain for patients suffering from sickle cell disease.

How similar studies have performed: While the use of virtual reality in pain management is gaining interest, this specific application for sickle cell disease is relatively novel and has not been extensively tested in prior studies.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Adult (age \> 18 years) emergency department patient
* History of sickle cell disease
* Presenting to the emergency department due to acute pain related to sickle cell disease thought to be due to vaso-occlusive crisis

Exclusion Criteria:

* Prior enrollment in this study
* Presenting with a chief complaint suggestive of a complicated crisis (such as concern for acute chest syndrome, splenic sequestration, hepatic sequestration, pulmonary embolism) as determined by the clinical care provider
* Not being treated with intravenous opioids for the vaso-occlusive crisis
* Patients who lack the capacity to provide informed consent
* Medical history of seizures or known intolerance to virtual reality
* Disabilities like vision and hearing defects etc. that preclude the use of a head mounted virtual reality device.
* Known to be pregnant
* Incarcerated at the time of evaluation
* Over the age of 89 years old

Where this trial is running

Baltimore, Maryland

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Sickle Cell Disease, Vaso-occlusive Pain Episode in Sickle Cell Disease, Acute Pain

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.