Condition

Sickle Cell Anemia clinical trials and research

• 10Clinical trials
• 28NIH research projects
• 11Countries

Newest Sickle Cell Anemia clinical trials

All recruiting trials (10)

• Checking measles vaccine response in children with sickle cell disease

  This study tests whether infants and young children with sickle cell disease develop enough protection in the weeks after their measles vaccine.

  Recruiting at 3 sites Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio and 2 other locations · NCT07356050

• Senicapoc for Sickle Cell Disease with Hemolytic Phenotype

  A mid-stage study tests whether daily senicapoc helps people with sickle cell disease who have ongoing red blood cell breakdown and low hemoglobin, despite hydroxyurea, by comparing it to a placebo over 24 weeks.

  Recruiting at 4 sites Phase 2 Biossil Inc. · Toronto, Ontario and 3 other locations · NCT07282210

• Tracking growth, puberty, fertility, and pregnancy in people with sickle cell anemia

  This study will see if taking hydroxyurea changes growth, puberty, fertility, or pregnancy outcomes in people with sickle cell anemia.

  Recruiting at 3 sites Children's Hospital Medical Center, Cincinnati · Santo Domingo and 2 other locations · NCT07116772

• Assessing pain tolerance, balance, and strength in children with sickle cell anemia

  This study is testing how pain tolerance, balance, and muscle strength differ between healthy kids and those with sickle cell anemia to help create safe exercise guidelines for them.

  Recruiting Cairo University · Giza · NCT06529874

• Using alendronate to treat osteonecrosis in adults with sickle cell disease

  This study is testing if a weekly medication called alendronate can help adults with sickle cell disease who have bone pain from osteonecrosis feel better and improve their bone health.

  Recruiting Phase 2 University of California, Davis · Sacramento, California · NCT06016634

• Evaluating a single dose of CTX001 for treating transfusion-dependent beta-thalassemia and severe sickle cell disease

  This study is testing a single dose of a new treatment called CTX001 to see if it can help people with transfusion-dependent beta-thalassemia or severe sickle cell disease feel better.

  Recruiting at 6 sites Phase 3 Vertex Pharmaceuticals Incorporated · New York, New York and 5 other locations · NCT05477563

• Haploidentical stem cell transplantation for sickle cell disease

  This study is testing a new type of stem cell transplant for people with sickle cell disease to see if it can cure the disease while causing fewer complications.

  Recruiting at 4 sites Phase 2 University of Regensburg · Vienna and 8 other locations · NCT04201210

• Understanding hydroxyurea effects during pregnancy and breastfeeding in women with sickle cell disease

  This study looks at how taking hydroxyurea during pregnancy and breastfeeding affects women with sickle cell disease and their babies to better understand the risks and outcomes.

  Recruiting Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT04093986

• Transplanting stem cells from mismatched donors for sickle cell disease and other anemias

  This study is testing if using stem cells from mismatched donors can help people with severe sickle cell disease and other anemias who don't have matching donors.

  Recruiting Phase 1/2 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT03653338

• Collecting blood samples to study sickle cell disease

  This study is collecting blood samples from healthy people and those with sickle cell disease to see if new drugs can help stop red blood cells from sickling.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT00542230

NIH-funded research (28)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Hydroxyurea to help children with sickle cell anemia in Africa

  A pediatric study tests hydroxyurea treatment for young children with sickle cell anemia in several African countries to see if it can reduce illness and improve health.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11606512

• Hydroxyurea for Children with Sickle Cell in Africa

  A pilot study tests hydroxyurea in young children with sickle cell disease across several African countries to see if it can reduce illness and hospital visits.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11606510

• Hydroxyurea for Children with Sickle Cell Disease in Africa

  A safe and feasible use of hydroxyurea for young children with sickle cell disease in several African countries to reduce illness and improve daily life.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11606509

• Hypoxemia during Sleep in Sickle Cell Disease: How Common is It and How Might Treatments Help

  This study looks at how low oxygen during sleep affects adults with sickle cell disease and how they respond to therapy across multiple urban and rural sites.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11416641

• Hypoxic red blood cells for sickle cell anemia using the Hemanext ONE system

  A new approach using special low-oxygen red blood cells from the Hemanext ONE system is being tested to help adults and children with sickle cell anemia who rely on frequent transfusions.

  NIH research New Health Sciences, INC. · Lexington, UNITED STATES · NIH-11415142

• Hydroxyurea for Children with Sickle Cell Anemia in Africa

  A safety and feasibility pilot study tests giving hydroxyurea to young children with sickle cell anemia in sub-Saharan Africa to reduce illness and death.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11414854

• Hydroxyurea for children with sickle cell anemia in sub‑Saharan Africa

  This project gives hydroxyurea to young children with sickle cell anemia in sub‑Saharan Africa to find safe dosing and reduce sickle‑related complications.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11399211

• Hydroxyurea for young children with sickle cell anemia in sub‑Saharan Africa

  This project gives hydroxyurea to young children with sickle cell anemia in sub‑Saharan Africa to reduce painful crises, hospital stays, and early death.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11399210

• Hydroxyurea for young children with sickle cell anemia in sub-Saharan Africa

  Hydroxyurea is given to young children with sickle cell anemia in sub-Saharan Africa to improve health and reduce sickle-related complications.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11399209

• Hydroxyurea treatment for young children with sickle cell anemia in Africa

  Giving hydroxyurea to young children with sickle cell anemia in several African countries to reduce sickle-related problems while monitoring safety.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11399208

• Hydroxyurea treatment for children with sickle cell anemia in sub-Saharan Africa

  Hydroxyurea given to young children with sickle cell anemia in sub-Saharan Africa to reduce pain, infections, and early death.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11384188

• A fast, at-a-glance genetic test for recently transfused sickle cell patients in low-resource settings

  A new quick, inexpensive genetic test could give accurate sickle cell results right after a blood transfusion, even in low-resource clinics.

  NIH research Rice University · Houston, United States · NIH-11377345

• Ischemic and neurometabolomic contributors to brain health in sickle cell anemia

  This grant studies why people with sickle cell anemia have cognitive problems, looking at brain blood flow, oxygen use, and other brain signals to understand who is at risk and why.

  NIH research Washington University · Saint Louis, United States · NIH-11305795

• Hydroxyurea for children with sickle cell anemia in Africa

  This project gives hydroxyurea to young children with sickle cell anemia in sub-Saharan Africa to help reduce pain crises, hospital visits, and early death while monitoring safety.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11167449

• Predicting kidney disease worsening in adults with sickle cell anemia

  Using computer learning to spot which adults with sickle cell anemia are most likely to have their kidney disease get worse.

  NIH research University of Tennessee Health Sci Ctr · Memphis, United States · NIH-11161553

• A quick test for sickle cell anemia in children who have received blood transfusions

  This project aims to create a fast, affordable test for sickle cell anemia in young children, especially those in areas with limited resources who have recently had a blood transfusion.

  NIH research Rice University · Houston, United States · NIH-11115639

• Understanding brain function and injury in children with sickle cell anemia

  This study is looking at how stress on the body affects brain growth and thinking skills in kids with sickle cell anemia, even if they haven't had a stroke, to find ways to help them avoid long-term learning challenges.

  NIH research Washington University · Saint Louis, United States · NIH-11076225

• Using flaxseed to reduce pain and inflammation in children with sickle cell anemia

  This study is looking at whether adding flaxseed to the diet can help reduce pain caused by inflammation in children with sickle cell anemia, and it will involve giving some kids flaxseed products while others get a placebo to see how it affects their pain and gut health.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11056151

• Understanding how oxygen supply affects brain development in children with sickle cell anemia

  This study is looking at how the way oxygen is used in the brain affects children with sickle cell anemia, especially regarding their brain growth and development, to help improve their care and health outcomes.

  NIH research Washington University · Saint Louis, United States · NIH-11045650

• Developing new drugs for Sickle Cell Anemia

  This study is looking for new medicines to help people with Sickle Cell Disease by using a special imaging technique to find ways to stop red blood cells from sickling, which can lead to better health for patients.

  NIH research Emory University · Atlanta, United States · NIH-11036330

• Improving preventive care for children with sickle cell anemia

  This study is looking to find out why many kids with sickle cell anemia aren't getting the check-ups and treatments they need, so we can come up with better ways to help them stay healthy and feel their best.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10929946

• Using machine learning to predict kidney disease progression in sickle cell anemia

  This study is looking at how computer models can help predict kidney problems in people with sickle cell anemia by checking things like protein levels in urine and genetic information, so we can find those who might need extra care early on to keep their kidneys healthy.

  NIH research University of Tennessee Health Sci Ctr · Memphis, United States · NIH-10903806

• Investigating ovarian health in women with sickle cell anemia

  This study is looking at how sickle cell anemia and its treatment with hydroxyurea might affect women's ability to have children, helping to provide important information for women with this condition about their reproductive health.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10901879

• Understanding how the brain uses oxygen in sickle cell anemia patients

  This study is looking at how well the brain uses oxygen in people with sickle cell anemia to understand why some may have silent strokes that could affect their thinking later on, and it aims to help doctors find those at greater risk for problems and improve their care.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-10901203

• Understanding spleen health in children with sickle cell anemia in sub-Saharan Africa

  This study is looking at how sickle cell anemia affects the spleen in children living in sub-Saharan Africa, especially since they often have an enlarged spleen, and it will check how this changes before and after they take a medicine called hydroxyurea.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-10873120

• Investigating brain health in children with sickle cell anemia in Uganda

  This study is looking at how sickle cell anemia affects children's brains in Uganda, especially focusing on hidden brain injuries that can impact their thinking and increase stroke risk, while also testing a treatment called hydroxyurea to help protect their brains over two and a half years.

  NIH research Global Health Uganda, LTD · Kampala, Uganda · NIH-10855068

• Investigating the effects of hydroxyurea on brain health in children with sickle cell anemia in Uganda

  This study is looking at how hydroxyurea treatment can help improve brain health and lower the chances of strokes in young children with sickle cell anemia in Uganda, and it will follow kids aged 2 to 9 over three years to see how the treatment affects their brain and overall health.

  NIH research Global Health Uganda, LTD · Kampala, Uganda · NIH-10696189

• Screening for developmental delays in children with sickle cell disease

  This study is looking at how sickle cell disease can affect the development and thinking skills of young children, so we can help kids aged 0-11 get the support they need early on to do better in school.

  NIH research Washington University · Saint Louis, United States · NIH-10685968

Related topics

Quick answers

How many Sickle Cell Anemia clinical trials are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in United States (6 trials), Tanzania (2 trials), Germany (2 trials), Ghana (1 trial), Canada (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 3: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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