Using Real-World Data to Improve Infection Prevention in Children with Sickle Cell Disease
Official title: Using Real-World Data to Evaluate Modern Pharmacotherapy Treatment Regimens and Prophylaxis for Reducing Infections in Sickle Cell Disease
Funded at Vanderbilt University Medical Center · NIH-11451018 · Data updated 2026-11-12
This project uses real-world data to understand how current antibiotic and disease-modifying therapies work together to prevent serious infections in children with sickle cell disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | August 15, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $873,449 |
| NIH project number | 1R01HL183867-01A1 |
| Project ID | NIH-11451018 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children with sickle cell disease who are represented in the SCDC data (across Georgia, Michigan, and Tennessee).
✕Less likely to help
Children with SCD whose treatment patterns are not captured in the SCDC data or who do not receive antibiotic prophylaxis or disease-modifying therapies.
What this research studies
If enrolled, I would be looked at through a health data lens to see how different treatments—like antibiotic prophylaxis and drugs such as hydroxyurea, L-glutamine, or crizanlizumab—affect infection risk and hospitalizations. Researchers will analyze large health data from the Sickle Cell Data Collection network across Georgia, Michigan, and Tennessee to observe outcomes over time. The goal is to identify which real-world treatment patterns are associated with fewer infections and better health for kids with SCD. This work uses existing medical records and population data to draw connections between therapies and infection-related complications.
Why it matters
Potential benefit: If successful, findings could guide doctors on optimizing treatment combinations to reduce infections and hospital stays for children with SCD.
How similar studies have gone: Population-based analyses of treatment patterns have shown associations between therapy combinations and infection outcomes in SCD, but this study emphasizes modern regimens and real-world data.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Wiese, Andrew David — Vanderbilt University Medical Center
- Study coordinator: Wiese, Andrew David
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.