Condition
Sickle Cell Anemia (HbSS, or HbSβ-thalassemia0) clinical trials and research
Research outlook What's coming for Sickle cell disease: the next 6 months to 5 yearsAs of November 12, 2026, Find a Trial lists 3 Sickle Cell Anemia (HbSS, or HbSβ-thalassemia0) clinical trials that are recruiting, in United States. By phase: Phase 1 (2), Phase 2 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 3Clinical trials
- 1Country
Newest Sickle Cell Anemia (HbSS, or HbSβ-thalassemia0) clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Hematopoietic stem cell editing to treat sickle cell disease | Phase 1 | Boston, Massachusetts | Recruiting | Jul 16, 2026 |
| Empagliflozin to protect kidney function in sickle cell anemia with albuminuria | Phase 2 | Chicago, Illinois | Recruiting | Sep 16, 2025 |
| Gene editing of your own blood stem cells to boost fetal hemoglobin for severe sickle cell disease and beta-thalassemia | Phase 1 | Boston, Massachusetts | Recruiting | Oct 18, 2024 |
All recruiting trials (3)
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Hematopoietic stem cell editing to treat sickle cell disease
This study tests whether a patient’s own blood stem cells can be edited to remove the sickle cell triggering gene and then returned to the patient.
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Empagliflozin to protect kidney function in sickle cell anemia with albuminuria
This study tests whether taking empagliflozin can slow kidney decline in people with sickle cell anemia and albuminuria.
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Gene editing of your own blood stem cells to boost fetal hemoglobin for severe sickle cell disease and beta-thalassemia
This trial will test whether editing a specific gene in patients' own blood stem cells can raise fetal hemoglobin and reduce symptoms in people aged 13–40 with severe sickle cell disease or transfusion-dependent beta-thalassemia.
Related topics
Quick answers
How many Sickle Cell Anemia (HbSS, or HbSβ-thalassemia0) clinical trials are recruiting right now?
3, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
All of them have sites in United States. Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 1: 2, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.