Digital cognitive rehabilitation for youth with sickle cell disease
Advancing Feasibility and Acceptability of Digital Cognitive Rehabilitation in Sickle Cell (ALL IN)
NA · Children's National Research Institute · NCT06770010
This study is testing a digital program that helps kids and teens with sickle cell disease improve their thinking skills and memory while also providing social support.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 7 Years to 16 Years |
| Sex | All |
| Sponsor | Children's National Research Institute (other) |
| Locations | 1 site (Washington D.C., District of Columbia) |
| Trial ID | NCT06770010 on ClinicalTrials.gov |
What this trial studies
This pilot clinical trial evaluates the feasibility and acceptability of a digital cognitive rehabilitation program for children and adolescents aged 7-16 with sickle cell disease. The intervention combines Cogmed working memory training with social support and memory strategy training to enhance adherence and cognitive performance. The study aims to address cognitive deficits associated with sickle cell disease, which can significantly impact the quality of life and neurological health of affected youth. By incorporating social elements and support, the program seeks to improve engagement and outcomes in cognitive training.
Who should consider this trial
Good fit: Ideal candidates are children and adolescents aged 7-16 diagnosed with sickle cell disease who exhibit cognitive deficits.
Not a fit: Patients with motor, visual, or auditory impairments that prevent computer use or those with significant mental health conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly enhance cognitive function and quality of life for youth with sickle cell disease.
How similar studies have performed: While few studies have explored cognitive rehabilitation in sickle cell disease, recent research on similar cognitive training programs has shown promising results.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Diagnosis of sickle cell disease (any genotype). 2. Between ages 7-16 years old. 3. Patients will only enter the treatment phase if they score \>1 SD below the normative mean on at least one standardized working memory assessment (i.e., Digit Span or Spatial Span subtests) or demonstrate a relative weakness in working memory (\>1 SD below the estimated IQ). Exclusion Criteria: 1. Motor, visual, or auditory impairment that prevents computer use. 2. Diagnosis of a mental health condition that precludes, or takes treatment precedence over, participation in the cognitive training. 3. History of photosensitive seizures. 4. Insufficient English fluency. 5. Recent initiation or dose adjustment of a stimulant medication to treat attention problems (\< 30 days).
Where this trial is running
Washington D.C., District of Columbia
- Children's National Hospital — Washington D.C., District of Columbia, United States (RECRUITING)
Study contacts
- Principal investigator: Steven Hardy, PhD — Children's National Research Institute
- Study coordinator: Steven Hardy, PhD
- Email: sjhardy@childrensnational.org
- Phone: 202-476-5000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Sickle Cell Disease