Adapting a fatigue-management program for adults with sickle cell disease
Official title: Adapting the FACETS Fatigue Management Program to Sickle Cell Disease
Run by Versailles Hospital · NCT06650813 · Data updated 2026-11-12
This trial will test a combined cognitive-behavioral and energy-conservation program (Drépa-FACETS) to reduce fatigue in French-speaking adults with sickle cell disease.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 24 (estimated) |
| Sponsor | Versailles Hospital Academic / other |
| Locations | 2 sites (Grenoble and 1 other locations) |
| Status | Recruiting |
| Started | January 10, 2025 |
| Main results expected | May 2, 2026 |
| Study ends | May 2, 2026 |
| Registry record updated | August 19, 2025 |
| Trial ID | NCT06650813 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with a major sickle cell syndrome who can read and speak French and are not currently hospitalized for a vaso-occlusive crisis are ideal candidates.
✕Probably not a fit
Patients with other chronic conditions causing fatigue, severe psychiatric disorders, current vaso-occlusive crises or those who cannot participate in French-language sessions are unlikely to benefit from this program.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The study adapts the FACETS program—an approach that combines cognitive-behavioral techniques with practical energy-conservation strategies—for adults living with sickle cell disease. Participants who speak French will attend program sessions and complete home exercises while researchers collect fatigue and related quality-of-life measures. People with severe psychiatric illness, other chronic causes of fatigue, or who are currently hospitalized for vaso-occlusive crisis are excluded. The intervention is delivered at hospital sites in France and outcomes will compare baseline and post-program fatigue symptoms.
Why it matters
Potential benefit: If successful, the program could reduce daily fatigue and improve functioning and quality of life for adults with sickle cell disease.
How similar studies have gone: Similar FACETS-style programs have shown benefit for fatigue in conditions like multiple sclerosis and other chronic illnesses, but adapting this approach specifically for sickle cell disease is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participant having freely given his oral agreement. * Participant with a major sickle cell syndrome, regardless of genotype (e.g. SS, SC, Sbeta). * Participant with a sufficient command of spoken and written French to take the assessments, complete the questionnaires, follow the program sessions and carry out the home exercises. Exclusion Criteria: * Participant with one or more severe psychiatric pathologies (e.g. severe depression, psychosis) that could interfere with the conduct of the study, in particular the primary and secondary endpoints. * Participants with another chronic pathology causing fatigue. * Participants in vaso-occlusive crisis (VOC) or hospitalization. * Participant under legal protection (guardianship, curatorship, safeguard of justice, deprived of liberty).
Where it's running
-
CHU Grenoble Alpes
Grenoble, France Recruiting -
Hospital Versailles
Le Chesnay, France Completed
Study contacts
- Study coordinator: Michalina DANNOUNE
- Email: mdannoune@ght78sud.fr
- Phone: 0139638856
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Cooling During Inpatient Rehab for People with MS
This trial tests whether wearing a cooling vest during intensive training can reduce fatigue and improve walking, strength, balance, and cognition in people with multiple sclerosis during a 3-week inpatient rehab stay.
-
Cerebrovascular Reactivity Testing with HD-DOT in Sickle Cell Patients
This study tests whether high-density diffuse optical tomography can measure brain blood flow and oxygen use in people with sickle cell disease, to see how these signals relate to stroke risk.
-
Adapting and testing PEN-Plus in Zambian primary care
Aiming to see if the PEN-Plus package can be adapted and used in two Zambian hospitals to better manage chronic diseases like heart disease, diabetes, hypertension, and sickle cell in primary care.
-
Collagen and omega-3 supplements in middle-aged women
This study tests whether taking collagen and omega-3s together improves joint pain, fatigue, sleep, and overall wellbeing in healthy women aged 35–65 compared with a placebo over 8 weeks.
-
Creatine or placebo to test effects on cognition, muscle strength, and body composition in middle-aged women
This study tests whether taking creatine daily for 8 weeks improves thinking, strength, fatigue, and body composition in healthy middle-aged women compared to a placebo.
-
Newborn Sickle Cell Screening in Mozambique
We’re testing a three-part plan to help babies in Mozambique get diagnosed early for sickle cell disease and start care quickly.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.