Understanding how individual differences shape pain in sickle cell disease (MIDAS)
Official title: Modeling Inter-individual Differences to Address Pain of Sickle cell disease (MIDAS)
Funded at University of Texas Arlington · NIH-11419821 · Data updated 2026-11-12
Aims to build a patient-focused model using real-world health data from Black adolescents and young adults with sickle cell disease to better predict and manage severe pain crises.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Arlington NIH-funded |
| Lab location | 1 site (Arlington, United States) |
| Project start | September 18, 2025 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $985,352 |
| NIH project number | 5R01HL178882-02 |
| Project ID | NIH-11419821 on NIH RePORTER |
Who could benefit from this research
✓Could help
Black adolescents and young adults with sickle cell disease experiencing severe pain or ADEs who can participate in long-term health data collection.
✕Less likely to help
Patients who do not have sickle cell disease or who cannot participate in long-term data collection may not benefit.
What this research studies
This project will longitudinally collect comprehensive health data from Black AYAs with sickle cell disease to create advanced models that identify who is at highest risk for painful crises and opioid-related problems. Researchers will clinically phenotype patients with difficult-to-control pain and adverse drug effects, then analyze genetic variants related to drug metabolism and pain perception to understand their impact on pain experiences. The goal is to develop a practical risk-stratification approach that clinicians can use to personalize pain management and reduce hospitalizations.
Why it matters
Potential benefit: If successful, patients could receive more personalized pain care and fewer hospital stays.
How similar studies have gone: Previous work shows meaningful links between pharmacogenetic variants and pain responses, supporting a similar approach in this project.
Where this research is happening
-
University of Texas Arlington
Arlington, United States Active
Researchers
- Principal investigator: Manworren, Renee — University of Texas Arlington
- Study coordinator: Manworren, Renee
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.