Targeting leukemia metabolism with metabolic imaging in AML
Official title: Interrogation of the oxidative-stress-induced leukemia program in vivo using metabolic imaging
Funded at Sloan-Kettering Inst Can Research · NIH-11360586 · Data updated 2026-11-12
Researchers are testing a new way to image and target the energy metabolism of acute myeloid leukemia to find vulnerabilities that could lead to better treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $705,462 |
| NIH project number | 5R01CA283578-04 |
| Project ID | NIH-11360586 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with acute myeloid leukemia or related myeloblastic/myelocytic leukemia subtypes who may benefit from metabolism-targeted approaches and advanced imaging.
✕Less likely to help
Patients whose AML does not rely on the studied metabolic pathways or who cannot undergo advanced imaging may not benefit.
What this research studies
This project investigates how AML cells depend on glycolysis and one-carbon metabolism, using advanced metabolic imaging to reveal vulnerabilities. By focusing on the PHGDH enzyme and related metabolic pathways, the study aims to identify strategies that selectively affect leukemia cells while sparing normal blood cells. The work builds on prior imaging and metabolic findings to test whether inhibiting this metabolic axis can improve treatment responses in AML. The approach combines cutting-edge imaging with molecular targeting to translate metabolic insights into potential therapies.
Why it matters
Potential benefit: If successful, the research could lead to new metabolic-targeted therapies or imaging-guided treatment strategies for AML patients.
How similar studies have gone: Previous studies have shown that targeting leukemia metabolism can be a promising approach, with supportive preclinical data guiding this work.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Keshari, Kayvan R — Sloan-Kettering Inst Can Research
- Study coordinator: Keshari, Kayvan R
Related research
Other NIH-funded projects on the same topics.
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Understanding how metabolism drives acute myeloid leukemia
This research explores how specific metabolic changes in leukemia cells could lead to new ways to treat acute myeloid leukemia (AML), especially for patients whose disease returns or resists current treatments.
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Exploring how oxidative stress affects leukemia using advanced imaging techniques
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Investigating how oxidative stress affects leukemia using advanced imaging techniques
This study is looking at how stress in the body affects the way leukemia cells use sugar to grow, with the goal of finding new ways to treat acute myeloid leukemia (AML) and help patients feel better.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.