Opioid-Free vs Opioid-Based Anesthesia for Thyroid Surgery
Official title: Effects of Opioid-Free and Opioid-Based Anesthesia on Perioperative Oxidative Stress Biomarkers in Euthyroid Adult Patients Undergoing Elective Thyroidectomy: A Prospective Clinical Trial
Run by Malatya Egitim Ve Arastirma Hastanesi · NCT07864155 · Data updated 2026-11-12
This study tests whether a non-opioid anesthesia approach can match or improve outcomes for adults undergoing thyroidectomy.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 110 (estimated) |
| Sponsor | Malatya Egitim Ve Arastirma Hastanesi Government |
| Locations | 1 site (Malatya) |
| Status | Recruiting |
| Started | April 1, 2026 |
| Main results expected | January 31, 2027 |
| Study ends | March 31, 2027 |
| Registry record updated | October 7, 2026 |
| Trial ID | NCT07864155 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18–65 years undergoing elective thyroidectomy, with ASA I–II, euthyroid status, and ability to consent.
✕Probably not a fit
Patients who do not experience reduced oxidative stress or who have contraindications to non-opioid components may see no additional benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
In this randomized, single-center trial, adults aged 18–65 with elective thyroidectomy are assigned to either opioid-free anesthesia using multimodal non-opioid analgesia (including dexmedetomidine and lidocaine) or fentanyl-based opioid anesthesia, with standard general anesthesia otherwise. The primary endpoint is perioperative oxidative stress, measured through serum thiol/oxidant markers and the oxidative stress index at three time points surrounding surgery. Secondary outcomes include pain, need for rescue opioids, nausea and vomiting, recovery characteristics, and intraoperative hemodynamic stability. Blood samples are collected before anesthesia, shortly after extubation, and about 24 hours post-surgery. The study aims to determine if removing intraoperative opioids alters the biochemical stress response and clinical recovery profile in euthyroid thyroidectomy patients.
Why it matters
Potential benefit: If opioid-free anesthesia reduces oxidative stress or improves recovery, patients could experience fewer opioid-related side effects and smoother postoperative courses.
How similar studies have gone: Prior work suggests that non-opioid, multimodal anesthesia can be feasible, but specific effects on oxidative stress in thyroid surgery are less established and require confirmation.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients aged 18 to 65 years * Scheduled for elective thyroidectomy * American Society of Anesthesiologists physical status I-II * Euthyroid status, defined as thyroid-stimulating hormone, free thyroxine, and free triiodothyronine levels within the reference range * Able to understand the study procedures and provide written informed consent Exclusion Criteria: * Uncontrolled advanced systemic disease, including advanced cardiac, pulmonary, renal, or hepatic failure * Active infection * Use of high-dose antioxidant supplementation within the last month * Widespread inflammation related to malignancy * Known severe allergy or contraindication to any study medication * Refusal to participate in the study
Where it's running
-
Malatya Turgut Ozal University Faculty of Medicine, Malatya Training and Research Hospital
Malatya, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Leman Acun Delen, Associate Professor
- Email: leman.delen@ozal.edu.tr
- Phone: +904222118019
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Diabetes, Dementia, and Oxidative Stress: A look at Nox2-related markers
This study tests whether oxidative stress linked to Nox2 is related to dementia risk in adults with type 2 diabetes.
-
Training to reduce oxidative stress in knee OA
A six-week program compares supervised knee-strengthening training with a daily 6,000-step walking plan to see if it improves pain, function, and blood markers of cellular stress in people with knee osteoarthritis.
-
Ashwagandha with resistance training to boost strength and stress markers
This 12-week study tests whether taking ASHWAGANDHA along with regular resistance training helps healthy, trained men see improvements in strength, stress levels, sleep, and cognitive function compared with a placebo.
-
Oxidative Stress and Heart Risk in People with Rheumatoid Arthritis
This study tests whether certain markers of oxidative stress in people with rheumatoid arthritis are linked to subclinical atherosclerosis and arterial stiffness, which could relate to future heart disease risk.
-
NVTIA Ergothioneine for Healthy Aging and Skin Health
This study tests whether taking NVTIA Ergothioneine daily for 12 weeks helps healthy adults age more gracefully and keeps skin looking and feeling better compared with a placebo.
-
Pumpkin seed oil for people on hemodialysis
This study tests whether taking pumpkin seed oil daily for 3 months helps reduce inflammation and improve-related lab markers in people with end-stage kidney disease on dialysis.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.