Pumpkin seed oil for people on hemodialysis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this randomized, open-label study, adults on maintenance hemodialysis will receive pumpkin seed oil 1000 mg daily in addition to usual care or usual care alone for 3 months. The trial will assess changes in inflammatory and oxidative stress biomarkers and related cardiovascular risk indicators. Enrollment targets 85 participants, with 45 in the pumpkin seed oil arm and 40 in the control arm, at Al-Karama Teaching Hospital in Baghdad. The study builds on preclinical and early clinical data suggesting anti-inflammatory and antioxidant effects of pumpkin seed oil. No pharmacologic anti-inflammatory agent is being tested.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* End-stage renal disease (ESRD) on hemodialysis for more than 6 months, on a constant dialysis program.
* Hemodynamically stable (no recent hospitalization for infections, cardiovascular events, or major surgery within the past 3 months).
* No active acute infections.
* Serum albumin ≥ 3.0 g/dL.

Exclusion Criteria:

* Regular intake of dietary supplements (e.g., omega-3, antioxidants) for at least one month prior to enrollment.
* Autoimmune disease, liver disease, cancer, or acquired immunodeficiency syndrome (AIDS).
* Known sensitivity/allergy to pumpkin seed oil.
* Current use of lipid-lowering agents.
* Diabetes mellitus.
* Current use of anticoagulants (warfarin, direct oral anticoagulants).
* Current use of immunosuppressants, corticosteroids, or anti-inflammatory drugs.
* Pregnant or breastfeeding women.
* Residual kidney function (urine output \> 200 mL/day).

Where it's running

• Al-Karama Teaching Hospital, Hemodialysis Center
  Baghdad, Karkh, Iraq Recruiting

Study contacts

• Study coordinator: mohammed mahmood M mohammed, professor
• Email: pharm.drmhdclinical@uomustansiriyah.edu.iq
• Phone: 07816871131

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.