Molecular clues about how Salmonella handles oxidative stress
Official title: Molecular determinants of oxidative stress in Salmonella pathogenesis
Funded at University of Colorado Denver · NIH-11369883 · Data updated 2026-11-12
This grant explores how Salmonella bacteria survive the body's attack during infection, which could lead to better treatments for dangerous non-typhoidal Salmonella illnesses.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | August 16, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $494,246 |
| NIH project number | 5R01AI136520-08 |
| Project ID | NIH-11369883 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with Salmonella infections or those at risk of severe disease could benefit from future treatments informed by this research.
✕Less likely to help
Healthy individuals or populations not affected by Salmonella likely would not benefit directly.
What this research studies
If funded, researchers will study how Salmonella uses its own metabolic tricks to resist the toxic oxygen compounds produced by immune cells. The project looks at how the bacteria adapt to low-oxygen conditions inside cells and in inflamed tissues. The findings could point to new ways to prevent or treat serious Salmonella infections that affect vulnerable populations. The work involves experiments in cells and mouse models to uncover the key survival strategies of the bacteria.
Why it matters
Potential benefit: A better understanding of Salmonella survival could guide the development of new therapies to reduce severe infections and deaths.
How similar studies have gone: Previous work has shown that Salmonella uses anaerobic respiration to survive in immune cells, supporting potential for new interventions.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Vazquez-Torres, Andres — University of Colorado Denver
- Study coordinator: Vazquez-Torres, Andres
Related research
Other NIH-funded projects on the same topics.
-
How vitamin B12 helps the gum-disease bacterium survive
Learning how vitamin B12 helps the bacteria that cause gum disease survive and become more harmful for people with periodontitis.
-
Pancreatic beta cells, oxidative stress, and gestational diabetes
A study is exploring how oxidative stress and changes in pancreatic beta cells during pregnancy may contribute to gestational diabetes and future diabetes risk for both mother and baby.
-
Environmental air pollutants linked to preeclampsia risk in pregnancy
This study looks at whether common air pollutants called PAHs increase the risk of preeclampsia during pregnancy.
-
Oxidative stress and Nlrp3 inflammasome activation in eye lens aging
This grant looks at how aging and oxidative stress drive inflammation in the eye lens, which could help prevent age-related eye diseases.
-
Glyphosate exposure and young adults' metabolic health
A study will look at how glyphosate exposure relates to metabolism and liver health in young adults, using urine measurements and health data.
-
Protein translation control in heart failure under oxidative stress
This project looks at how heart cells manage oxidative stress and how a protein called Nrf2 is produced, which could reveal new ways to help people with heart failure.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.