Different root canal sealers and salivary oxidative stress in chronic apical periodontitis.
Evaluation of Oxidative Stress in Patients With Chronic Apical Periodontitis Treated With Single Session Root Canal Treatment Using Different Root Canal Sealers: in Vivo Study
This test will compare two types of root canal sealers to see if they change saliva oxidative stress markers in adults with chronic apical periodontitis.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | All |
| Sponsor | Ordu University Academic / other |
| Locations | 1 site (Ordu, Ordu- Altınordu) |
| Trial ID | NCT07059481 on ClinicalTrials.gov |
What this trial studies
Adults with chronic apical periodontitis who meet eligibility criteria will receive single-session root canal treatment using either a bioceramic-based or an epoxy resin-based sealer. Saliva samples will be collected at the time of treatment and again 30 days later to measure oxidative stress markers and total oxidant status, and periapical index (PAI) scores will be recorded radiographically. The primary comparison is the change in salivary oxidative markers between the two sealer groups. Participants will be informed about procedures and must be systemically healthy, non-smokers, and able to attend the follow-up visit.
Who should consider this trial
Good fit: Ideal candidates are systemically healthy adults aged 18–45, non-smokers, with a devitalized multi-rooted tooth and a radiographic lesion under 2 cm who can attend baseline and 30‑day visits.
Not a fit: Patients with systemic illness, smokers, pregnant or lactating women, those with poor oral hygiene, recent antibiotic or analgesic use, or those unable to attend follow-up are unlikely to benefit or be eligible.
Why it matters
Potential benefit: If successful, the results could help dentists choose a sealer that lowers oxidative stress and may support better healing after root canal treatment.
How similar studies have performed: Prior work indicates endodontic treatment can change oxidative markers, but direct comparisons between bioceramic and epoxy resin sealers on salivary oxidative stress are limited, making this a relatively novel comparison.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Systemically healthy, ASA1 patients, * Phase 1 periodontal treatment was performed, * Diagnosed with chronic apical periodontitis in a single tooth with 2 or more roots in the mouth, * The lesion measured \<2 cm on radiographic evaluation, * The vitality of the tooth was checked by EPT (Ai-Pex, Woodpecker, China) and Cold test (Cerkamed, Poland) and confirmed to be devitalised, * Socioculturally able to participate in the treatment, * Individuals who did not smoke or drink alcohol Exclusion Criteria: * Patients who have used antibiotics in the last three months and analgesics in the last two weeks * Patients who smoke and/or abuse alcohol * Patients younger than 18 years or older than 45 years, * Patients with controlled or uncontrolled systemic disease and life-threatening conditions (ASA 2,3,4,5,6) * Pregnant or lactating women, * Patients with poor oral hygiene, * Patients who had head and neck radiotherapy, * With obesity, * Active periodontal disease, * Periodontal pocket depth over 3mm, * There is enough loss of material in the relevant tooth to prevent adequate isolation or to require post placement, * Clinical examination of the relevant tooth showing symptoms in percussion-palpation, * Radiographically, the lesion is seen in relation to anatomical formations such as the mandibular canal and maxillary sinus, * Patients who required prophylactic antibiotic use before invasive dental procedures were excluded from the study. * Patients who did not attend the follow-up appointment and patients who experienced complications during expansion (instrument seperation, perforation, etc.) were excluded from the study.
Where this trial is running
Ordu, Ordu- Altınordu
- Ordu University — Ordu, Ordu- Altınordu, Turkey (Türkiye) (Recruiting)
Study contacts
- Study coordinator: Bengi Gülgü
- Email: bengigulgu@gmail.com
- Phone: +905330262002
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.