Different root canal sealers and salivary oxidative stress in chronic apical periodontitis.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with chronic apical periodontitis who meet eligibility criteria will receive single-session root canal treatment using either a bioceramic-based or an epoxy resin-based sealer. Saliva samples will be collected at the time of treatment and again 30 days later to measure oxidative stress markers and total oxidant status, and periapical index (PAI) scores will be recorded radiographically. The primary comparison is the change in salivary oxidative markers between the two sealer groups. Participants will be informed about procedures and must be systemically healthy, non-smokers, and able to attend the follow-up visit.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Systemically healthy, ASA1 patients,
* Phase 1 periodontal treatment was performed,
* Diagnosed with chronic apical periodontitis in a single tooth with 2 or more roots in the mouth,
* The lesion measured \<2 cm on radiographic evaluation,
* The vitality of the tooth was checked by EPT (Ai-Pex, Woodpecker, China) and Cold test (Cerkamed, Poland) and confirmed to be devitalised,
* Socioculturally able to participate in the treatment,
* Individuals who did not smoke or drink alcohol

Exclusion Criteria:

* Patients who have used antibiotics in the last three months and analgesics in the last two weeks
* Patients who smoke and/or abuse alcohol
* Patients younger than 18 years or older than 45 years,
* Patients with controlled or uncontrolled systemic disease and life-threatening conditions (ASA 2,3,4,5,6)
* Pregnant or lactating women,
* Patients with poor oral hygiene,
* Patients who had head and neck radiotherapy,
* With obesity,
* Active periodontal disease,
* Periodontal pocket depth over 3mm,
* There is enough loss of material in the relevant tooth to prevent adequate isolation or to require post placement,
* Clinical examination of the relevant tooth showing symptoms in percussion-palpation,
* Radiographically, the lesion is seen in relation to anatomical formations such as the mandibular canal and maxillary sinus,
* Patients who required prophylactic antibiotic use before invasive dental procedures were excluded from the study.
* Patients who did not attend the follow-up appointment and patients who experienced complications during expansion (instrument seperation, perforation, etc.) were excluded from the study.

Where it's running

• Ordu University
  Ordu, Ordu- Altınordu, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Bengi Gülgü
• Email: bengigulgu@gmail.com
• Phone: +905330262002

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.