Reactive Oxygen Species and Reproduction (ROAR)
Official title: The ROAR Study: Reactive Oxygen Species and Reproduction
Run by University of California, San Francisco · NCT06831019 · Data updated 2026-11-12
This study will see if oxidative stress levels in follicular fluid, blood, and sperm are linked to egg quality and IVF success for couples undergoing blastocyst culture with PGS.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 43 Years |
| Sex | All |
| Enrollment | 1100 (estimated) |
| Sponsor | University of California, San Francisco Academic / other |
| Locations | 1 site (San Francisco, California) |
| Status | Recruiting |
| Started | July 7, 2025 |
| Main results expected | March 1, 2027 |
| Study ends | March 1, 2027 |
| Registry record updated | February 17, 2026 |
| Trial ID | NCT06831019 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are UCSF patients age 18–43 undergoing IVF with planned blastocyst culture and PGS whose male partners are available and present on the day of retrieval.
✕Probably not a fit
Patients planning fresh embryo transfer, cleavage-stage biopsy, use of frozen sperm, or who are not treated at UCSF are unlikely to qualify or benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective cohort at UCSF enrolling women age 18–43 undergoing IVF with planned blastocyst culture and preimplantation genetic screening (PGS) and their male partners. Researchers will measure oxidative stress markers in follicular fluid, serum, and sperm collected on the day of egg retrieval and correlate those levels with oocyte competence judged by embryo development and pregnancy outcomes. The study will analyze the combined oxidative stress burden of each couple against IVF laboratory results and clinical pregnancy rates. Patients planning fresh transfer, cleavage-stage biopsy, or using frozen sperm are excluded, and both partners must be present on retrieval day.
Why it matters
Potential benefit: If successful, this could identify oxidative stress markers that predict oocyte competence and IVF success, guiding personalized interventions to improve outcomes.
How similar studies have gone: Previous observational studies have linked oxidative stress markers to poorer IVF outcomes but results have been inconsistent, making this prospective couple-level approach relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Female age 18-43 years 2. Subjects planning blastocyst culture for preimplantation genetic screening (PGS) for aneuploidy. 3. Male partners 18 years of age or older. 4. Must be a registered patient at UCSF Center for Reproductive Health 5. Patient and partner must both be physically present on the day of retreival Exclusion Criteria: 1. Female partner age 44 or older 2. Planning fresh transfer (hybrid PGS cycle) 3. Cleavage stage biopsy 4. Planning to use frozen sperm
Where it's running
-
University of California, San Francisco
San Francisco, California, United States Recruiting
Study contacts
- Principal investigator: Mitchell Rosen, MD — University of California, San Francisco
- Study coordinator: Elena Hoskin, BS
- Email: elena.hoskin@ucsf.edu
- Phone: (415) 885-3598
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.