Understanding how oxidative stress affects proteins and cells to improve treatments for radiation-related damage
Official title: Structural systems biology of microenvironmental oxidative stress and synthetic biology intervention
Funded at Albert Einstein College of Medicine · NIH-11331282 · Data updated 2026-11-12
Scientists are studying how oxidative stress harms proteins in bacteria and human cells to pinpoint targets that could help diagnose and treat radiation-related damage and aging.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | August 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $420,000 |
| NIH project number | 5R35GM151236-04 |
| Project ID | NIH-11331282 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with conditions involving oxidative stress or radiation exposure who could benefit from improved diagnostics or therapies in the future.
✕Less likely to help
Healthy individuals without oxidative stress-related risk may not benefit directly.
What this research studies
The project uses a structural systems biology approach to map how oxidative stress alters protein function in E. coli and human cells. It will combine genome-scale metabolic models with known and predicted protein structures to simulate stress effects on metabolism and identify bottlenecks. Researchers will validate predictions with proteomics, metabolomics, and enzyme activity tests under oxidative conditions. The work aims to identify protein targets that could guide future diagnostics and therapies for radiation toxicity and related conditions.
Why it matters
Potential benefit: If successful, this work could lead to new ways to diagnose and treat oxidative-stress–related damage from radiation and aging.
How similar studies have gone: Similar systems biology approaches have shown promise in predicting stress responses and identifying metabolic bottlenecks in cells under stress.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Chang, Roger Larken — Albert Einstein College of Medicine
- Study coordinator: Chang, Roger Larken
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.