Using fluorescent indicators to measure oxidative stress in Alzheimer's disease
Fluorescent Redox Indicators to Image Oxidative Stress in Alzheimer's Disease
This study is working on new tools to help scientists see how oxidative stress affects brain cells in mice with Alzheimer's disease, which could lead to better understanding and treatments for the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-11212190 on NIH RePORTER |
What this research studies
This research focuses on developing genetically encoded fluorescent redox indicators (GERIs) to evaluate oxidative stress in mouse models of Alzheimer's disease (AD). By optimizing these indicators, the researchers aim to create tools that can easily measure oxidative stress levels during the progression of AD and in response to treatments. The study is led by a team with expertise in fluorescence imaging and metabolic drivers of cognitive disorders, which will enhance the understanding of oxidative stress's role in neuron death. This innovative approach could significantly advance research on AD and its underlying mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are individuals at risk for or diagnosed with Alzheimer's disease, particularly those with age-related neurodegenerative conditions.
Not a fit: Patients with non-neurodegenerative conditions or those not affected by age-related cognitive decline may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and therapeutic strategies for Alzheimer's disease by providing insights into oxidative stress.
How similar studies have performed: Previous research has shown success in using fluorescent indicators for imaging oxidative stress in various biological contexts, suggesting a promising avenue for this novel application in Alzheimer's disease.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Ai, Huiwang — University of Virginia
- Study coordinator: Ai, Huiwang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.