Investigating how oxidative stress affects heart function in heart failure.
Oxidative Stress and Mitochondrial Dysfunction in Chemogenetic Heart Failure
['FUNDING_CAREER'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-11324071
This study is looking at how oxidative stress affects heart health, especially in people with heart failure, and it aims to find new ways to help treat this condition, particularly for premature infants who are more vulnerable to heart issues.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11324071 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the impact of oxidative stress on heart function, particularly in the context of heart failure. The principal investigator, Dr. Fotios Spyropoulos, will use a specialized mouse model to generate oxidative stress in the heart and study its effects on mitochondrial function and overall cardiac health. The research aims to uncover the mechanisms linking oxidative stress to heart failure, which could lead to new therapeutic strategies. The findings may eventually be applied to better understand heart failure in premature infants, who are at higher risk for such conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of heart failure or those at risk due to conditions like prematurity.
Not a fit: Patients with heart failure unrelated to oxidative stress or mitochondrial dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for heart failure, particularly in vulnerable populations like premature infants.
How similar studies have performed: Previous research has shown promising results in understanding oxidative stress and its role in heart conditions, indicating that this approach has potential for success.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SPYROPOULOS, FOTIOS — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: SPYROPOULOS, FOTIOS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.