Daily gazpacho to improve semen quality in men with reduced sperm parameters

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-center, randomized, open-label trial at GINEFIV (IVIRMA Madrid) comparing a standardized Mediterranean diet alone versus the same diet plus a daily 330 mL gazpacho for 12 weeks in men aged 18–45 with altered semen parameters. Participants are randomized 1:1 and provide semen samples at baseline and after 12 weeks; semen analysis follows WHO 2021 guidelines. Seminal oxidative stress will be measured with the OxiSperm II test (research use only) and two production batches of the gazpacho product will be analyzed for lycopene, vitamin C, and vitamin E. Adherence is tracked with a self-administered diary and scheduled follow-up calls.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Men aged 18 to 45 years
* Andrological profile including altered semen parameters such as oligozoospermia, asthenozoospermia and/or teratozoospermia (O±A±T)
* No clinical indication for sperm DNA fragmentation testing or advanced sperm selection techniques
* Willingness and ability to comply with the study protocol, including adherence to a standardized Mediterranean diet
* Signed and dated written informed consent form

Exclusion Criteria:

* Use of antioxidant supplements during the three months prior to study start.
* Active smokers or men who have stopped smoking within the last three months.
* Diagnosis of azoospermia, leucocytospermia or necrozoospermia.
* Presence of severe systemic diseases or chronic conditions that could interfere with semen quality or adherence to the study.
* Known allergy or intolerance to any ingredient of the gazpacho used in the study.
* Any medical, psychological or social condition that, in the investigator's judgement, could compromise the subject's ability to participate fully or comply with the protocol requirements.
* Simultaneous participation in another clinical study.

Where it's running

• GINEFIV Madrid (IVIRMA Group)
  Madrid, Madrid, Spain Recruiting

Study contacts

• Principal investigator: Pablo Martí Pastor, RD, RND — Ginefiv Madrid (IVIRMA Group)
• Study coordinator: Pablo Martí Pastor, RN, RDN
• Email: pablo.marti@ginefiv.com
• Phone: +34 669975090

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Probiotics to improve sperm count, motility, and morphology in men with low sperm quality

  This study tests whether daily probiotic supplements can improve sperm count, motility, and morphology in men with unexplained low sperm quality.

  Recruiting Mackay Memorial Hospital · New Taipei City · NCT07345455

• Evaluating a new method for sperm capacitation

  This study is testing a new method called HyperSperm to see if it can improve sperm quality for men who are having trouble with fertility.

  Recruiting at 4 sites Fecundis Lab SL · Barcelona, Barcelona and 3 other locations · NCT06742437

• Investigating the microbiome and HPV status in couples facing fertility issues

  This study is looking at how the bacteria in the body and HPV might affect couples trying to get pregnant, while also testing if probiotics can improve sperm quality in men with fertility issues.

  Recruiting Medical University of Graz · Graz, Styria · NCT05328999

• Diabetes, Dementia, and Oxidative Stress: A look at Nox2-related markers

  This study tests whether oxidative stress linked to Nox2 is related to dementia risk in adults with type 2 diabetes.

  Recruiting Neuromed IRCCS · Pozzilli · NCT07928453

• Opioid-Free vs Opioid-Based Anesthesia for Thyroid Surgery

  This study tests whether a non-opioid anesthesia approach can match or improve outcomes for adults undergoing thyroidectomy.

  Recruiting Malatya Egitim Ve Arastirma Hastanesi · Malatya · NCT07864155

• Training to reduce oxidative stress in knee OA

  A six-week program compares supervised knee-strengthening training with a daily 6,000-step walking plan to see if it improves pain, function, and blood markers of cellular stress in people with knee osteoarthritis.

  Recruiting Vrije Universiteit Brussel · Capelle aan den IJssel · NCT07845838

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.