How exposure to heavy metals, nanoparticles, and emerging contaminants relates to allergic skin and systemic metal reactions

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study will recruit three adult groups—patients with systemic metal allergic syndrome, patients with allergic contact dermatitis due to metals, and healthy controls—and collect environmental, biological, and clinical data. investigators will measure serum and urine concentrations of metals and nanoparticles, perform metal patch testing, record within-breath oscillometry parameters, and analyze serum zonulin and protein oxidation products. Environmental sampling and exposure histories will be obtained to link external exposures with biological markers. Results will be compared across the three groups to determine whether exposed patients show distinct biomarker or clinical profiles.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* adult subjects (over 18 years of age).
* Subjects suffering from allergic contact dermatitis due to metals.
* Subjects with systemic allergic syndrome due to metals.
* Adult healthy subjects.
* Subjects able to give written informed consent.

Exclusion Criteria:

* Subjects under the age of 18years.
* Pregnant/breastfeeding women.
* Subjects suffering from chronic renal failure requiring replacement treatment.
* Subjects suffering from other systemic pathologies related to exposure to metals.
* Subjects suffering from gastrointestinal diseases such as celiac disease, chronic inflammatory intestinal diseases, tumors, other skin diseases.
* Subjects unable to express written informed consent.

Where it's running

• Fondazione Policlinico Universitario A. Gemelli IRCCS
  Roma, Italy Recruiting
• Università di Bologna
  Bologna, Italy Not yet recruiting

Study contacts

• Principal investigator: Angela Rizzi, MD, PhD — Fondazione Policlinico Universitario Agostino Gemelli IRCCS
• Study coordinator: Angela Rizzi, MD, PhD
• Email: angela.rizzi@policlinicogemelli.it
• Phone: +390630154952

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.