Protein translation control in heart failure under oxidative stress
Official title: Protein Translation for Oxidative Stress Response in Heart Failure
Funded at University of Arizona · NIH-11404793 · Data updated 2026-11-12
This project looks at how heart cells manage oxidative stress and how a protein called Nrf2 is produced, which could reveal new ways to help people with heart failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | September 5, 2025 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $566,770 |
| NIH project number | 5R01HL179676-02 |
| Project ID | NIH-11404793 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with or at risk for heart failure or who have had myocardial ischemia/infarction, particularly those interested in participating in biomarker or mechanistic studies related to heart disease.
✕Less likely to help
Patients without heart-related conditions or those not contributing samples or data for mechanistic studies may not benefit directly.
What this research studies
Heart failure is a serious condition linked to oxidative stress. The research focuses on how heart cells selectively make protective proteins like Nrf2 during stress, potentially bypassing normal shutdown of protein production. Using advanced proteomics, the team will explore the role of YTHD2 and m6A marks in guiding Nrf2 mRNA to the ribosome. The goal is to uncover mechanisms that could be targeted to boost antioxidant responses in diseased heart tissue. If successful, these insights might lead to new strategies to improve heart function and outcomes for patients with heart failure.
Why it matters
Potential benefit: Better understanding of how the heart can better protect itself from oxidative damage, which could guide new treatments for heart failure.
How similar studies have gone: Prior work in this area has shown that selective translation mechanisms can influence stress responses in cardiac cells, supporting the potential for this line of inquiry.
Where this research is happening
-
University of Arizona
Tucson, United States Active
Researchers
- Principal investigator: Chen, Qin M — University of Arizona
- Study coordinator: Chen, Qin M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.