Training to reduce oxidative stress in knee OA

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study tests whether 6 weeks of guided exercise or a walking-based routine can improve symptoms and daily-life function in knee osteoarthritis. Participants start with a screening blood sample and complete symptom questionnaires, with follow-up assessments after the training period. The trial involves two groups: one receiving supervised training twice weekly, and another walking 6,000 steps per day. Outcomes include pain scores, functional measures, and blood markers of oxidative stress. The goal is to determine if physical activity can strengthen knee muscles and enhance overall fitness in this population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* diagnosed Knee osteoartritis in one or both knees

Exclusion Criteria:

* not able to walk 6000 steps
* not able to participate in the training

Where it's running

• Fysiotherapie de Rozenburcht
  Capelle aan den IJssel, Netherlands Recruiting

Study contacts

• Principal investigator: Aldo Scafoglieri, Prof — professor at VUB
• Study coordinator: Mariette boshuis-scheenstra
• Email: Mariette@rozenburcht.com
• Phone: +31102847365

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Diabetes, Dementia, and Oxidative Stress: A look at Nox2-related markers

  This study tests whether oxidative stress linked to Nox2 is related to dementia risk in adults with type 2 diabetes.

  Recruiting Neuromed IRCCS · Pozzilli · NCT07928453

• Effects of virtual reality on walking in adults with knee osteoarthritis

  This study tests how immersive virtual reality environments—designed to feel safe or to provoke fear—affect walking and worry about movement in adults 50 and older with knee osteoarthritis and in healthy peers.

  Recruiting University of Primorska · Vilnius and 1 other locations · NCT07920120

• Weekly berobenatide for knee osteoarthritis in adults who are overweight or obese

  This study tests whether weekly berobenatide helps reduce knee pain and improve function, while also affecting body weight, in adults with knee osteoarthritis who are overweight or obese (with or without type 2 diabetes).

  Recruiting Phase 3 Pfizer · Birmingham, Alabama and 3 other locations · NCT07915609

• Autologous adipose-derived stem cell injections for knee osteoarthritis

  We’re testing whether injecting a patient’s own fat-derived stem cells into the knee can help people with knee OA feel less pain and move better, compared with a standard hyaluronic acid treatment.

  Recruiting at 3 sites Yonsei University · Incheon and 2 other locations · NCT07901790

• Preoperative Multimorbidity and Functional Recovery After Total Knee Arthroplasty

  This study tests whether higher burden of preoperative multimorbidity affects functional recovery after knee replacement in adults with knee osteoarthritis.

  Recruiting Balikesir Ataturk City Hospital · Balıkesir · NCT07882316

• Cartilage biomarker response to acute loading in knee OA by antiresorptive treatment status

  Researchers will test whether a 30-minute treadmill walk changes cartilage biomarkers in postmenopausal women with knee osteoarthritis, comparing those on denosumab, bisphosphonates, and those not on antiresorptives.

  Recruiting Sisli Hamidiye Etfal Training and Research Hospital · Istanbul, Istanbul · NCT07881861

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.