Lower Airway Microbes and Oxidative Stress in Inflammatory Lung Disease
Official title: Lower Airway Microbial Sulfur Metabolism and Oxidative Stress in Inflammatory Lung Disease
Funded at New York University School of Medicine · NIH-11356103 · Data updated 2026-11-12
A study to understand how microbes in the lungs influence oxidative stress and inflammation in lung diseases, with a focus on how smoking-related damage and sulfur compounds affect patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 20, 2026 |
| Project end | April 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $254,250 |
| NIH project number | 1R21AI199100-01 |
| Project ID | NIH-11356103 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with inflammatory airway diseases (e.g., COPD) and variations in lung microbiome and oxidative stress markers.
✕Less likely to help
Individuals without inflammatory airway disease or those not experiencing oxidative stress-related pathology may see limited relevance.
What this research studies
This project will look at how the bacteria living in the lungs contribute to redox balance and inflammation in lung diseases. Using measurements of oxidative stress markers and lung microbiome profiles, researchers will explore how microbial metabolites and sulfur chemistry relate to disease severity. The goal is to map connections between lung microbes, sulfur compounds, and lung function to identify potential pathways for therapy. The work is designed with patient relevance in mind, aiming to uncover targets that could lead to better management of inflammatory airway diseases.
Why it matters
Potential benefit: If successful, the findings could inform new approaches to reduce oxidative damage and improve lung function in patients with inflammatory airway diseases.
How similar studies have gone: Prior research shows the lung microbiome can influence lung metabolism and inflammation, suggesting this approach may yield meaningful insights.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Wong, Kendrew King Hao — New York University School of Medicine
- Study coordinator: Wong, Kendrew King Hao
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.