Investigating how microRNA-210 affects oxidative stress in patients with peripheral artery disease
The role of microRNA-210 in regulating oxidative stress in patients with peripheral artery disease
This study is looking at how a tiny molecule called microRNA-210 affects muscle health in people with peripheral artery disease (PAD) and how it might help doctors create better, personalized treatments for patients after they have surgery to improve blood flow.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of West Florida NIH-funded |
| Lab location | 1 site (Pensacola, United States) |
| Project ID | NIH-11220628 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of microRNA-210 in patients with peripheral artery disease (PAD), a condition affecting millions of Americans. The study aims to identify how microRNA-210 influences gene expression related to oxidative stress and mitochondrial function in skeletal muscle. By employing an omics approach, researchers will analyze the downstream targets of microRNA-210 and assess how these changes relate to patient outcomes, particularly after revascularization procedures. This could lead to personalized treatment strategies based on individual biomarker profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 40 years of age diagnosed with peripheral artery disease, particularly those experiencing intermittent claudication or critical limb ischemia.
Not a fit: Patients without peripheral artery disease or those under 40 years of age may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and treatment options for patients with peripheral artery disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of microRNAs in various diseases, suggesting that this approach could yield valuable insights for PAD as well.
Where this research is happening
Pensacola, United States
- University of West Florida — Pensacola, United States (Active)
Researchers
- Principal investigator: Koutakis, Panagiotis — University of West Florida
- Study coordinator: Koutakis, Panagiotis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.