Investigating how microRNA-210 affects oxidative stress in patients with peripheral artery disease
Official title: The role of microRNA-210 in regulating oxidative stress in patients with peripheral artery disease
Funded at University of West Florida · NIH-11220628 · Data updated 2026-11-12
This study is looking at how a tiny molecule called microRNA-210 affects muscle health in people with peripheral artery disease (PAD) and how it might help doctors create better, personalized treatments for patients after they have surgery to improve blood flow.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of West Florida NIH-funded |
| Lab location | 1 site (Pensacola, United States) |
| Project start | August 15, 2019 |
| Project end | March 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $521,511 |
| NIH project number | 7R01AG064420-07 |
| Project ID | NIH-11220628 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 40 years of age diagnosed with peripheral artery disease, particularly those experiencing intermittent claudication or critical limb ischemia.
✕Less likely to help
Patients without peripheral artery disease or those under 40 years of age may not benefit from this research.
What this research studies
This research focuses on understanding the role of microRNA-210 in patients with peripheral artery disease (PAD), a condition affecting millions of Americans. The study aims to identify how microRNA-210 influences gene expression related to oxidative stress and mitochondrial function in skeletal muscle. By employing an omics approach, researchers will analyze the downstream targets of microRNA-210 and assess how these changes relate to patient outcomes, particularly after revascularization procedures. This could lead to personalized treatment strategies based on individual biomarker profiles.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and treatment options for patients with peripheral artery disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of microRNAs in various diseases, suggesting that this approach could yield valuable insights for PAD as well.
Where this research is happening
-
University of West Florida
Pensacola, United States Active
Researchers
- Principal investigator: Koutakis, Panagiotis — University of West Florida
- Study coordinator: Koutakis, Panagiotis
Related research
Other NIH-funded projects on the same topics.
-
Improving exercise rehabilitation for Veterans with peripheral artery disease
This study is looking to improve exercise rehabilitation for Veterans with peripheral artery disease (PAD) by understanding how factors like oxidative stress and inflammation affect their ability to exercise, so we can create better treatments that help them get moving again.
-
Low-dose colchicine to reduce vascular risk in people with peripheral artery disease
This project tests whether taking a low-dose anti-inflammatory drug (colchicine) daily can lower heart and limb-related risks for adults with peripheral artery disease.
-
How vitamin B12 helps the gum-disease bacterium survive
Learning how vitamin B12 helps the bacteria that cause gum disease survive and become more harmful for people with periodontitis.
-
Gamified home walking program to help seniors with peripheral artery disease improve walking and quality of life
A program uses game elements on wearable devices to help people 65+ with peripheral artery disease walk more at home and feel better.
-
Pancreatic beta cells, oxidative stress, and gestational diabetes
A study is exploring how oxidative stress and changes in pancreatic beta cells during pregnancy may contribute to gestational diabetes and future diabetes risk for both mother and baby.
-
Environmental air pollutants linked to preeclampsia risk in pregnancy
This study looks at whether common air pollutants called PAHs increase the risk of preeclampsia during pregnancy.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.