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Clinical trial Recruiting at 1 site Interventional Ages 18 to 65

Red propolis supplementation for people with chronic kidney disease

Official title: Red Propolis as a Strategy to Modulate Inflammation and Oxidative Stress in Patients With Chronic Kidney Disease

Run by Universidade Federal Fluminense · NCT07597005 · Data updated 2026-11-12

This study tests whether taking red propolis daily for 8 weeks can reduce inflammation and oxidative stress in people with chronic kidney disease who are managed without dialysis.

Quick facts

Study typeInterventional
Ages18 Years to 65 Years
SexAll
Enrollment40 (estimated)
SponsorUniversidade Federal Fluminense
Academic / other
Locations1 site (Rio de Janeiro, Rio de Janeiro)
StatusRecruiting
StartedSeptember 30, 2025
Main results expectedNovember 30, 2025
Study endsAugust 31, 2027
Registry record updatedMay 19, 2026
Trial IDNCT07597005 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults with CKD stages 3–5 who are managed conservatively and not on dialysis.

Probably not a fit

Patients with uncontrolled infections, autoimmune diseases, cancer, liver disease, AIDS, pregnancy, lactation, or recent antibiotic/antioxidant use may not benefit or could be at risk.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, double-blind, placebo-controlled trial will give alcoholic extract of red propolis (200 mg per day) or placebo for 8 weeks to adults with CKD stages 3–5 under conservative management. The study will measure inflammatory and oxidative stress markers in blood, along with routine lab values and gene expression related to inflammation and oxidative stress, to see if red propolis has a beneficial effect. Nutritional status and dietary intake will also be tracked to account for potential confounders. The goal is to determine whether red propolis can modulate biological pathways linked to CKD progression and associated complications.

Why it matters

Potential benefit: If successful, red propolis could help lessen inflammation and oxidative stress in CKD, potentially slowing disease progression and improving health markers.

How similar studies have gone: There is limited clinical evidence on red propolis in CKD, with no prior studies assessing gene expression related to inflammation and oxidative stress in this population.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* patients with CKD stages 3-5 under conservative management

Exclusion Criteria:

* pregnant,
* lactating,
* smoker
* patients using antibiotics and antioxidant supplements in the last three months
* patients with autoimmune and infectious diseases,
* patients with cancer, liver disease, and AIDS

Where it's running

  • Denise Mafra
    Rio de Janeiro, Rio de Janeiro, Brazil     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Kidney Disease 432Oxidative Stress 182Chronic Kidney Disease 283Universidade Federal Fluminense 8
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.