Hyperuricemia and gum disease: is uric acid linked to bone loss in periodontitis?

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will collect gum-fluid and blood samples from 18- to 65-year-olds, measuring periodontal health and uric acid-related biomarkers to explore links between hyperuricemia, inflammation, oxidative stress, and bone metabolism. The study will compare participants who are periodontally healthy with those who have periodontitis, including individuals with and without hyperuricemia. No intervention is given beyond sample collection, and all data will be analyzed to identify potential mechanisms connecting uric acid levels to periodontal disease. The work is observational and aims to clarify whether systemic uric acid status may influence periodontal outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Being between 18 and 65 years of age
* Being systemically healthy or diagnosed with hyperuricemia
* Having at least 20 natural teeth
* Being periodontally healthy or diagnosed with periodontitis

Exclusion Criteria:

* Diabetes, cardiovascular disease, osteoporosis, chronic kidney disease, metabolic syndrome, and obesity are systemic diseases that may affect purine metabolism.
* Smoking
* Pregnancy or lactation
* Having received periodontal treatment within the last 3-6 months
* Use of antibiotics, anti-inflammatory drugs, or uric acid-lowering drugs
* Presence of systemic diseases that may affect purine metabolism

Where it's running

• Recep Tayyip Erdoğan University
  Rize, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Hatice Yemenoglu
• Email: htcymnglu@hotmail.com
• Phone: +905052977517

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.