Condition
Malignant Solid Neoplasm clinical trials and research
As of November 12, 2026, Find a Trial lists 97 Malignant Solid Neoplasm clinical trials that are recruiting, at sites in 10 countries (most in United States (97), Puerto Rico (5), Canada (3)). By phase: Phase 2 (7), Phase 3 (6), Phase 1 (3), Early Phase 1 (2). The most active sponsors are Mayo Clinic (30), M.D. Anderson Cancer Center (11), City of Hope Medical Center (9). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 97Clinical trials
- 10Countries
Newest Malignant Solid Neoplasm clinical trials
All recruiting trials (97)
-
See if virtual informed consent methods help people decide to join cancer research
This trial tests whether virtual human communicators and different consent messages can influence cancer patients’ understanding and willingness to participate in research.
-
AI-powered supportive care chatbot for young adult cancer survivors
A chatbot driven by artificial intelligence is tested to help young adult cancer survivors manage symptoms and care needs after treatment.
-
Telehealth pharmacist-led opioid education for cancer patients
This pilot tests a telehealth group education session led by a palliative care pharmacist to help adults with cancer use opioids more safely and effectively.
-
Mindfulness program to help with symptoms in chronic graft-versus-host disease
A mindfulness-based program is being tested to see if it can reduce patient-reported symptoms for adults with chronic graft-versus-host disease after a stem cell transplant.
-
Non-invasive brain stimulation to help chemotherapy-induced nerve problems in cancer survivors
This trial tests whether a gentle brain stimulation method (tDCS) can help reduce numbness, tingling, and pain from CIPN in cancer survivors who are not currently in treatment.
-
Couples Coping Together Against Cancer: A Feasibility and Acceptability Look
This observational study tests whether a brokered program for patients with cancer and their partners is feasible and acceptable, and whether it may reduce distress over time.
-
Ambient sensor rooms to spot early problems in hospitalized cancer patients
This test will try whether special hospital rooms with cameras, microphones, and temperature sensors can help staff spot early delirium, falls, sleep problems, or mood changes in adults hospitalized with cancer.
-
Voices: sharing messages of wisdom and hope during illness
This project will see if recording semi-structured interviews with adult cancer patients (and optional caregivers) affects patients' sense of dignity and caregiver support.
-
Virtual LASO-3 diet program to ease chemotherapy-related numbness and tingling
This trial tests whether a virtual diet program that lowers added sugar and increases fiber and omega-3s can help cancer survivors who have numbness, tingling, or pain after neurotoxic chemotherapy.
-
Culturally tailored patient navigation to shorten time from cancer diagnosis to treatment for American Indian and Alaska Native people in rural California
This project will try a culturally tailored patient navigation program to shorten delays between cancer diagnosis and treatment for American Indian and Alaska Native adults living in rural California.
-
How doctors' behaviors affect distress during radiation therapy
This study will see if certain physician behaviors during radiation therapy change how much distress adults with cancer experience.
-
Interest in integrative oncology services at USC Norris Cancer Center
This project will see if adult patients with solid tumors or blood cancers at USC Norris and Keck HC3 are interested in and able to use integrative oncology services and what barriers might limit participation.
-
Virtual Mindfulness-Based Stress Reduction program for underserved Minnesota cancer patients
This program tests if a virtual mindfulness-based stress reduction (MBSR) course can reduce emotional distress and improve mental well-being for cancer patients in underserved or rural parts of Minnesota.
-
Web-based CONNECT toolkit to reduce emotional distress and anxiety in rural older cancer survivors
We will test whether CONNECT, a web-based toolkit, can help reduce cancer-related emotional distress and anxiety in rural adults over 65 who have finished cancer treatment.
-
In-home cancer treatment with remote specialist support for patients in the Florida Panhandle
This program will try giving standard cancer treatments at home to people living in the Florida Panhandle and nearby areas to see if they prefer it and have better treatment satisfaction.
-
Educational program to support goals of care conversations for patients with solid cancers
A-PACT is a program where trained lay health workers help adults with solid tumors talk with their care teams about goals of care and end-of-life preferences to see if it lowers unplanned hospital visits.
-
Immune Cells in Blood and Tissues After Allogeneic Transplant and Chronic GVHD
This study tests whether immune cells in blood and other samples differ between people who develop chronic GVHD after an allogeneic transplant and those who don’t.
-
Virtual reality to reduce psychological symptom burden during cancer treatment
This trial will try virtual reality sessions to reduce anxiety, depression, and adjustment symptoms for adults receiving cancer treatment.
-
L-theanine for relaxation and mood support in cancer patients on surveillance
This trial tests whether taking 200 mg of L-theanine once or twice daily for six weeks can help relaxation and mood in adult cancer patients who have finished treatment and are in surveillance.
-
Viewing your street in virtual reality: original versus digitally altered opposite streetscape
This test shows adult neighborhood residents short virtual reality scenes of either their actual street or a digitally altered ‘opposite’ version to see if those views change stress, emotion, and physiological responses.
-
Different types of massage to reduce anxiety during chemotherapy infusion
This trial tests whether 30-minute massages to different body areas during chemo infusions can reduce anxiety in adult cancer patients who report at least moderate anxiety.
-
Growing immune cells outside the body to study neoantigen cancer vaccines (ACT-X)
This project tests how immune cells from people with or without solid tumors react to a new neoantigen vaccine by collecting blood or apheresis samples.
-
Virtual community health educator to boost referrals to cancer clinical programs for patients and caregivers
This study tests whether a photo-realistic virtual community health educator can help cancer patients and their caregivers get more referrals to cancer clinical programs.
-
Aromatherapy with peppermint, lavender, or ginger to ease anxiety and nausea during outpatient chemotherapy infusions
This research will test whether inhaling peppermint, ginger, or lavender essential oils can reduce nausea and anxiety for adults getting outpatient chemotherapy infusions.
-
Vanguard: a new blood test approach to screen for multiple cancers
This study will test two different blood-based multi-cancer detection tests in adults 45–75 without cancer to see if they find cancers earlier than usual care.
-
Guided meditation to reduce anxiety before cancer surgery
This study tests if listening to a guided meditation can help reduce anxiety in patients getting ready for cancer surgery compared to wearing noise-canceling headphones.
-
Virtual solution-focused brief therapy for emotional distress in adolescent and young adult cancer survivors
This project tests whether short, virtual solution-focused therapy helps adolescents and young adults (ages 15–39) who are cancer survivors reduce anxiety and depression compared with enhanced usual care.
-
Better quality-of-life questions for adolescents and young adults with cancer
This project will test how adolescents and young adults with cancer (ages 15–39) and their caregivers in the U.S. answer quality-of-life questions so the questions can be improved.
-
Memory and physical activity in adolescent and young adult cancer survivors
This project will see if physical activity is linked to thinking and memory in adults who were treated for cancer between ages 15 and 39.
-
Using fucoidan to prevent fatigue in cancer patients undergoing chemotherapy
This study tests if a seaweed supplement called fucoidan can help cancer patients undergoing chemotherapy feel less tired.
-
Breathing practice to improve brain and mental health in cancer and MS patients
This study tests whether breathing exercises through a mobile app can help improve brain and mental health for people with cancer and multiple sclerosis, along with their caregivers.
-
Unrestricted cash payments for early-stage cancer patients to help with costs
This trial tests whether giving a monthly unrestricted cash card to newly diagnosed early-stage cancer patients with financial concerns can help with financial hardship and support their treatment.
-
Using acupressure to reduce anxiety in cancer patients undergoing treatment
This study tests if acupressure can help reduce anxiety and nausea in cancer patients undergoing chemotherapy and improve their overall quality of life.
-
Telehealth support for caregivers of cancer patients
This study tests if a telehealth support program can help caregivers of cancer patients feel less stressed about money and depression while improving their confidence and satisfaction in caring for their loved ones.
-
Modeling cancer treatment side effects using patient blood samples
This study is trying to see how cancer treatments affect the body by using blood samples from patients to create special cells that can help researchers understand side effects like heart and nerve damage.
-
Using wearable devices to prevent hospitalizations during cancer treatment
This study is testing whether using wearable devices can help predict and prevent hospital visits for patients getting radiation therapy for cancer.
-
Genetic testing to prevent cancer in Indigenous American communities
This study is trying to see if genetic testing can help prevent cancer and improve treatment for Indigenous American communities in the Southwest.
-
Community exercise and nutrition program for cancer survivors
This study is testing a 12-week exercise and nutrition program to see if it can help cancer survivors feel healthier and improve their quality of life.
-
Observing sex differences in symptoms during cancer immunotherapy
This study looks at the different symptoms men and women experience during cancer immunotherapy to see how their reports match up with what doctors observe.
-
A tool to help cancer patients overcome travel challenges for radiation therapy
This study is testing a new tool to help cancer patients with solid tumors get to their radiation therapy appointments more easily and see if it helps them stick to their treatment better.
-
Using triptorelin to protect ovaries in young cancer patients during chemotherapy
This study is testing if triptorelin can help protect the ovaries of young cancer patients under 40 during chemotherapy to see if it helps maintain their fertility and overall health later on.
-
Video education to boost knowledge and interest in cancer clinical trials
Adults in the Detroit area will watch a short educational video to see if it increases their knowledge about and interest in cancer clinical trials.
-
Using cryocompression and cilostazol to prevent nerve damage from chemotherapy in women with gynecological cancers
This study is testing if using cryocompression therapy alone or with a medication called cilostazol can help prevent nerve damage from chemotherapy in women with gynecological cancers.
-
Improving access to genetic testing for underserved cancer patients
This study is testing whether a computer character can give better information about genetic testing to underserved cancer patients compared to regular human healthcare providers.
-
Early detection of cognitive side effects from immunotherapy
This project tests whether an automated toolkit called SALSA can find early cognitive side effects in adults receiving CAR-T immunotherapy.
-
Culturally-tailored mobile and social media program to increase physical activity in Hispanic/Latino adolescent and young adult childhood cancer survivors.
This project will test whether a culturally tailored home-based physical activity program delivered via mobile tools and social media can help Hispanic/Latino adolescent and young adult childhood cancer survivors become more active.
-
Using Wisconsin ginseng to reduce cancer-related fatigue
This study is testing if Wisconsin ginseng can help reduce fatigue in cancer patients compared to a placebo over eight weeks.
-
Identifying heart risks in cancer patients after chemotherapy
This study is trying to find out why some cancer patients have heart problems after chemotherapy while others don't, by looking at their blood samples and medical records.
-
Using creative arts to help children with cancer
This study is testing if doing creative arts like drawing and painting can help children with cancer feel better and improve their quality of life compared to just watching videos.
-
Connecting underrepresented populations to clinical trials at Ohio State University
This study is trying to find better ways to connect racial and ethnic minorities to cancer clinical trials at Ohio State University to help them participate more.
-
Using light therapy after radiation to treat blocked airways from cancer
This study is testing if a light therapy treatment after radiation can help people with advanced cancer who have blocked airways breathe better and improve their quality of life.
-
Validation of blood and urine tests for early cancer detection
This study is testing if blood and urine tests can help find some of the deadliest cancers earlier in people who have them compared to those who don’t.
-
Helping cancer patients manage costs and financial stress
This study is testing a new program to help cancer patients manage their costs and financial stress to see if it improves their ability to stick to treatment and their overall quality of life.
-
Comparing different telephone methods for managing symptoms during cancer treatment
This study is testing three different phone-based support methods to see which one helps cancer patients manage their symptoms and feelings better during treatment.
-
Comparing home and clinic administration of nivolumab for cancer treatment
This study tests whether giving cancer patients their treatment at home instead of in a clinic makes them feel better and prefer their care more.
-
Virtual group therapy to improve psychological wellbeing in cancer patients
This study is testing if virtual group therapy that combines acceptance and commitment therapy with compassion can help improve the mental wellbeing of cancer patients.
-
Community-based exercise program for cancer survivors
This study tests a 12-week exercise program for cancer survivors to see if it helps them feel better and improves their quality of life.
-
Evaluating a new AI tool for radiation therapy planning
This study tests a new AI tool that helps medical staff at Mayo Clinic plan radiation therapy by automatically outlining important areas on CT scans to see if it makes their job easier and more accurate.
-
New blood and urine tests for cancer screening
This study is testing new blood and urine tests for cancer screening to see how well they work in people without known cancer and how different health factors might affect the results.
-
Using alteplase to improve fluid drainage and breathlessness in patients with malignant pleural effusion
This study tests if the medication alteplase can help people with fluid buildup in the lungs feel better and breathe easier when regular drainage isn’t enough.
-
Testing neratinib alone or with palbociclib for HER2 positive solid tumors
This study is testing if a new cancer treatment called neratinib works better alone or with another drug, palbociclib, for people with HER2 positive solid tumors, especially those with gynecologic cancers.
-
Using weighted blankets to reduce anxiety in cancer patients during infusions
This study is testing whether using weighted blankets can help reduce anxiety in cancer patients during their first infusion therapy.
-
Telemedicine support for older cancer patients in underserved communities
This study tests whether using telemedicine to provide extra support can help older cancer patients in underserved communities feel better and have fewer hospital visits compared to standard care.
-
Group sessions to help cancer patients manage stress
This study is testing if group sessions that teach cancer patients how to manage stress can help them feel better mentally and cope with their treatment.
-
Analyzing cancer genetics for better prevention and treatment
This study is trying to find genetic clues in cancer patients' samples to improve prevention and treatment options for cancer.
-
Understanding communication about immunotherapy between patients and providers
This study looks at how well patients and doctors talk about immunotherapy to see if better communication can help patients understand their treatment options.
-
Using PET scans to guide targeted radiation therapy for certain cancers
This study is testing if using PET scans to guide targeted radiation therapy can help people with certain cancers, like lung cancer and melanoma, get better results than standard treatment.
-
Improving genetic counseling for at-risk relatives of cancer patients
This study is testing if talking directly with a healthcare provider about genetic testing results can help at-risk family members of cancer patients get tested more often and feel better about it.
-
Letermovir to prevent cytomegalovirus after pediatric stem cell transplant
This study will try giving letermovir to CMV-positive children and adolescents receiving allogeneic stem cell transplants to see if it lowers CMV infections after transplant compared with the expected rate without prophylaxis.
-
Collecting blood and tissue samples for HIV/AIDS-related cancer research
This study is collecting blood and tissue samples from people living with HIV and related cancers to help researchers learn more about how HIV affects cancer development.
-
Comparing cooling and compression methods to prevent nerve damage from chemotherapy
This study is testing three different ways to help prevent nerve damage from chemotherapy in cancer patients receiving taxane-based treatments to see which method works best.
-
Group program to help young adult cancer survivors improve their quality of life
This study tests a 6-week online program designed to help young adult cancer survivors improve their quality of life by connecting with peers and learning coping skills.
-
Effect of spinal cord stimulation on pain and quality of life in chemotherapy-induced peripheral neuropathy
This study is testing if spinal cord stimulation can help reduce pain and improve quality of life for people dealing with nerve pain from chemotherapy.
-
Collecting blood samples to evaluate tests for early cancer detection
This study is collecting blood and tissue samples from people with and without cancer to see if new tests can help detect cancer earlier.
-
Combining vertebroplasty and radiation therapy for spine cancer patients
This study is testing whether combining a special type of radiation therapy with a procedure to strengthen the spine can help people with tough-to-treat cancer in that area feel better and live longer.
-
Understanding how gut bacteria influence cancer treatment
This study looks at how the bacteria in your gut might affect how well cancer treatments work for people with certain types of cancer.
-
Observing complications and responses in cancer patients treated with anti-VEGF therapies
This study looks at how cancer patients treated with anti-VEGF therapies respond to the treatment and what complications they might face.
-
Combining Tumor Treating Fields with Cabozantinib or Pembrolizumab and Nab-Paclitaxel for Advanced Solid Tumors
This study is testing a new treatment that combines tumor treating fields with two different cancer drugs to see if it helps people with advanced solid tumors in the abdomen or chest.
-
Creating guidelines for prostate cancer care using expert opinions
This study is trying to create clear guidelines for prostate cancer care by gathering opinions from experts to help doctors provide better and more consistent treatment for patients.
-
Examining how COVID-19 changed pulmonary procedures
This study looks at how doctors who treat lung conditions changed their procedures and staffing during the COVID-19 pandemic to see what worked best.
-
Geriatric evaluation and management program for older cancer survivors
This study is testing if a special program that combines health education and support can help older cancer survivors feel better and improve their daily life after finishing chemotherapy.
-
Predicting side effects from immune therapy in cancer patients
This study is trying to see if certain factors like age and medical history can help predict serious side effects in cancer patients receiving immune therapy, so doctors can make better treatment choices.
-
Expressive writing to help manage stress in cancer survivors
This study tests if writing about their experiences can help cancer survivors manage stress better than writing about neutral topics.
-
Impact of COVID-19 on young cancer patients and survivors
This study is trying to see how the COVID-19 pandemic has affected the mental, physical, and social well-being of young cancer patients and survivors aged 18 to 39.
-
Identifying and caring for individuals with inherited cancer syndromes
This study is testing whether free genetic testing can help find and support people with inherited cancer syndromes better than current methods.
-
Genetic testing for cancer in diverse ethnic groups
This study is testing how genetic testing can help cancer patients from different ethnic backgrounds understand their risks and improve their personalized care.
-
Collecting data and samples from patients with immunotherapy side effects
This study is collecting blood, tissue, and stool samples from patients who have serious side effects from immunotherapy to help understand and improve how to manage these reactions.
-
Real-time imaging of tumor blood vessels during surgery
We will test whether a real-time microscope technique during surgery can show how well blood vessels in adults' solid tumors work and whether that helps predict if systemic cancer medicines can reach the tumor.
-
Exploring gut microbiome and fecal transplant effects on GI issues in cancer patients
This study is testing how the gut bacteria affect stomach issues in cancer patients receiving certain treatments and whether a stool transplant can help relieve those problems.
-
Using nivolumab to treat patients with autoimmune disorders and advanced cancer
This study is testing if nivolumab can safely help people with autoimmune disorders who also have advanced cancer by looking at how well it works and what side effects it might cause.
-
Using targeted radiation therapy before or after surgery for brain tumors
This study is testing whether giving targeted radiation therapy before or after surgery helps people with metastatic brain tumors live longer and have fewer side effects.
-
Collecting and storing tissue and blood samples from cancer patients
This study is collecting and storing blood and tissue samples from cancer patients to help researchers create better models for understanding cancer and testing new treatments.
-
Using non-invasive ventilation to reduce intubation in cancer patients with respiratory failure
This study is testing if a breathing treatment called non-invasive ventilation can help cancer patients with respiratory failure avoid the need for a breathing tube compared to standard oxygen therapy.
-
Gathering health information for younger cancer patients
This study is gathering health information from younger cancer patients to help improve treatments and support future research.
-
Molecular testing for personalized cancer therapy at MD Anderson
This study is testing if looking at the genetic makeup of tumors in cancer patients can help find the best personalized treatments and match them with suitable clinical trials.
-
Collecting blood and tissue samples from patients with recurrent or metastatic prostate or bladder cancer
This study is collecting blood and tissue samples from patients with recurrent or advanced prostate or bladder cancer to see if they can find new ways to improve treatment and understand why some treatments don’t work.
-
Collecting data on side effects of proton therapy for cancer treatment
This study is trying to learn about the side effects that cancer patients experience after receiving proton therapy to help improve future treatments.
Related topics
Quick answers
How many Malignant Solid Neoplasm clinical trials are recruiting right now?
97, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 10 countries. The most sites are in United States (97 trials), Puerto Rico (5 trials), Canada (3 trials), Guam (2 trials), Australia (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 7, Phase 3: 6, Phase 1: 3, Early Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.